INT267758

Context Info Confidence 0.23 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.12

cytoplasm (Nlrp3)

Nlrp3 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 17 83.36 Inflammation 10 44.60 chemokine 6 38.36 tolerance 4 5.00 Pain 2 5.00 ketamine 1 5.00 Inflammatory response 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 1 97.28 INFLAMMATION 11 44.60 Immunization 22 42.48 Infection 37 5.00 Mitral Valve Prolapse 36 5.00 Chlamydia Infection 7 5.00 Weight Loss 1 5.00 Stress 1 5.00 Autoimmune Disease 1 5.00 Sprains And Strains 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alum induces the oligomerization of Nalp3, which in turn causes the recruitment of the adapter protein, ASC (apoptosis-associated specklike protein containing a caspase activation recruitment domain), to form a macromolecular complex called an inflammasome.

Positive_regulation (induces) of Nalp3 Binding (oligomerization) of associated with apoptosis

1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.10 Pain Relevance 0.12

General Comments

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