INT267800

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.79
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 2
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 164 99.32 Very High Very High Very High
anticonvulsant 4 96.84 Very High Very High Very High
tolerance 4 95.16 Very High Very High Very High
Oxycodone 1 88.60 High High
Pain 5 84.68 Quite High
Arthritis 1 84.48 Quite High
agonist 20 83.96 Quite High
Dopamine 28 83.60 Quite High
peripheral neuropathy 1 55.32 Quite High
Sciatica 1 54.28 Quite High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 217 100.00 Very High Very High Very High
Disease 28 100.00 Very High Very High Very High
Partial Seizures 1 99.00 Very High Very High Very High
Vomiting 7 92.36 High High
Fatigue 2 91.48 High High
Dizziness 9 91.12 High High
Sleep Disorders 37 90.68 High High
Hallucination 5 90.60 High High
Psychosis 2 89.16 High High
Sleep-wake Transition Disorders 1 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors such as natural progression of RLS, fluctuations in underlying disease severity, or different study designs in terms of inclusion criteria for patients might be responsible for the discrepancy noted in the different reports (Winkelman and Johnston 2004).
Spec (might) Regulation (responsible) of Gene_expression (progression) of RLS associated with disease and restless legs syndrome
1) Confidence 0.29 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671938 Disease Relevance 0.57 Pain Relevance 0.09
Gabapentin is an anticonvulsant drug and is approved in the United States for the treatment of postherpetic neuralgia7 and partial seizures.7–10 Gabapentin has also been shown effective in improving RLS symptoms, reducing the frequency of periodic leg movements and improving sleep quality, suggesting a potential role in treating RLS.11–15 Gabapentin is not approved for the indication of RLS treatment, although it is often used off-label for this purpose.5,16,17 Additional placebocontrolled, double-blind clinical trials have also suggested potential uses of gabapentin in the treatment of painful neuropathies in patients with diabetes mellitus18 and anxiety disorders.19
Regulation (improving) of Gene_expression (symptoms) of RLS in leg associated with pain, diabetes mellitus, anxiety disorder, anticonvulsant, restless legs syndrome, partial seizures and gabapentin
2) Confidence 0.26 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874339 Disease Relevance 1.52 Pain Relevance 0.86
The severity of RLS symptoms was assessed using the IRLSSG rating scale (IRLS) for RLS.24
Regulation (severity) of Gene_expression (symptoms) of RLS associated with restless legs syndrome
3) Confidence 0.24 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796069 Disease Relevance 1.70 Pain Relevance 0.12

General Comments

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