INT267805

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pln) protein complex (Pln)
Pln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 11 87.72 High High
Dopamine 14 87.40 High High
Gabapentin 12 50.80 Quite High
addiction 4 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
sSRI 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
tricyclic antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 218 95.56 Very High Very High Very High
Fatigue 5 63.60 Quite High
Disease 4 60.52 Quite High
Vomiting 4 51.52 Quite High
Sleep Disorders 50 50.00 Quite Low
Renal Disease 6 38.16 Quite Low
Chronic Renal Failure 7 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Anaemia 2 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be investigated, whether and how applying the unfolding procedure to larger and more homogeneous patient groups allows the association between PLM and clinical significance.
PLM Binding (association) of
1) Confidence 0.33 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2953451 Disease Relevance 0.07 Pain Relevance 0
In 10 patients, pramipexole was associated with a PLM-I of 1.7, compared with 68.0 for placebo (Montplaisir et al 1999).
PLM Binding (associated) of
2) Confidence 0.05 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671944 Disease Relevance 0.27 Pain Relevance 0.34
In a study of 30 patients, pergolide, in comparison with placebo, was associated with greater total sleep time (mean 373.6 minutes vs 261.9 minutes) and a reduced PLM-I (5.7 vs 55.0) (Wetter et al 1999).
PLM Binding (associated) of
3) Confidence 0.05 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671944 Disease Relevance 0.46 Pain Relevance 0.06

General Comments

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