INT267808

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.96
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Brain 2
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 130 99.76 Very High Very High Very High
agonist 60 98.28 Very High Very High Very High
antagonist 4 96.32 Very High Very High Very High
Central nervous system 1 95.16 Very High Very High Very High
Substantia nigra 4 91.00 High High
Arthritis 1 83.32 Quite High
imagery 1 81.88 Quite High
rheumatoid arthritis 2 66.04 Quite High
Eae 3 65.60 Quite High
dopamine receptor 6 62.28 Quite High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 419 100.00 Very High Very High Very High
Congenital Anomalies 1 99.12 Very High Very High Very High
Anaemia 14 98.60 Very High Very High Very High
Sleep Disorders 81 95.08 Very High Very High Very High
Hallucination 3 89.44 High High
Psychosis 2 88.00 High High
Sleep-wake Transition Disorders 2 86.72 High High
Renal Disease 2 86.32 High High
Athletic Injuries 1 84.48 Quite High
Neuropathic Pain 1 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain iron deficiency might cause abnormalities in dopaminergic systems and, consequently, induce RLS symptoms.14
Positive_regulation (induce) of Gene_expression (symptoms.14) of RLS in Brain associated with anaemia, congenital anomalies and restless legs syndrome
1) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.12 Pain Relevance 0.15
The severity of RLS improved on the IRLS with all three dosages of rotigotine.
Positive_regulation (severity) of Gene_expression (severity) of RLS associated with restless legs syndrome
2) Confidence 0.39 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671947 Disease Relevance 0.81 Pain Relevance 0.06
The severity of RLS symptoms was assessed using the IRLSSG rating scale (IRLS) for RLS.24
Positive_regulation (assessed) of Gene_expression (using) of RLS associated with restless legs syndrome
3) Confidence 0.27 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796069 Disease Relevance 1.63 Pain Relevance 0.12
An additional supportive clinical feature is the “improvement of RLS symptoms with DA therapy”.1,2,7

IRON LEVELS, TYROSINE HYDROXYLASE, CYTHOCROME P450, DA AND TH

Positive_regulation (improvement) of Gene_expression (symptoms) of RLS associated with dopamine and restless legs syndrome
4) Confidence 0.12 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 1.48 Pain Relevance 0.20
At the present time, there is robust evidence that low iron levels are one of the causative factors of RLS or of increasing its severity.8–10 Diminished DA function has a role in RLS symptoms, as can be inferred from the fact that DA agonists are beneficial to RLS patients, whereas antagonists are detrimental, and low iron levels are a putative cause of decreased DA function.8
Positive_regulation (role) of Gene_expression (symptoms) of RLS associated with dopamine, antagonist, agonist and restless legs syndrome
5) Confidence 0.12 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.92 Pain Relevance 0.41

General Comments

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