INT267824

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (BCL2A1)
Anatomy Link Frequency
amygdala 2
BCL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 133 97.98 Very High Very High Very High
Anterior cingulate cortex 3 93.34 High High
positron emission tomography 4 91.92 High High
Pain 244 82.32 Quite High
imagery 16 75.00 Quite High
Central nervous system 3 63.28 Quite High
Peripheral nervous system 1 54.56 Quite High
Thalamus 6 51.92 Quite High
Pain matrix 10 36.20 Quite Low
Neuropeptide 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 97 98.52 Very High Very High Very High
Post-traumatic Stress Disorder 166 95.66 Very High Very High Very High
Pain 236 82.32 Quite High
Injury 35 74.32 Quite High
Sinus Arrhythmia 6 27.68 Quite Low
Nociception 10 27.60 Quite Low
Cognitive Disorder 8 20.52 Low Low
Stress 7 10.04 Low Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Mental Disorders 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also failed to demonstrate enhanced ACC activation in the empathy condition in our sample despite the fact that we observed a positive correlation of activation in ACC and individual differences in unpleasantness ratings.
Positive_regulation (enhanced) of Positive_regulation (activation) of ACC
1) Confidence 0.67 Published 2008 Journal Emotion Section Body Doc Link PMC2672051 Disease Relevance 0.20 Pain Relevance 0.23
PET studies of patients with PTSD show decreased anterior cingulate cortex (ACC, part of the PFC) activation to the emotional Stroop using fear-evoking words, such as “rape”;41 however, PTSD patients have normal mPFC activation to nonemotional interference tasks.41,42 Weakened mPFC control of the amygdala may be a risk factor for psychopathology: a recent study of children with depressed parents found a lack of ACC activation to the emotional Stroop, using both fear-relevant words depicting physical threat and social threat.43
Positive_regulation (lack) of Positive_regulation (activation) of ACC in amygdala associated with post-traumatic stress disorder, anxiety disorder, positron emission tomography, amygdala and anterior cingulate cortex
2) Confidence 0.49 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938301 Disease Relevance 1.12 Pain Relevance 0.58
This lack of increased ACC activation on a group level during the empathy condition parallels the findings of the Singer et al. (2006) study, which also only found reliable activation in ACC for the female participants (see also Singer et al., 2004), not for the male participants.
Positive_regulation (increased) of Positive_regulation (activation) of ACC
3) Confidence 0.45 Published 2008 Journal Emotion Section Body Doc Link PMC2672051 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

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