INT267844

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 15.35
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
liver 10
kidney 2
Ace (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 89.84 High High
cytokine 10 88.24 High High
Inflammation 43 85.28 High High
fibrosis 39 83.92 Quite High
metalloproteinase 41 66.32 Quite High
bradykinin 1 39.52 Quite Low
Hippocampus 2 16.32 Low Low
ischemia 10 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
palliative 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 574 100.00 Very High Very High Very High
Metastasis 560 99.96 Very High Very High Very High
Cancer 527 99.84 Very High Very High Very High
Duchenne Muscular Dystrophy 20 99.80 Very High Very High Very High
Muscular Dystrophy 140 99.64 Very High Very High Very High
Renal Disease 12 96.68 Very High Very High Very High
Hypertension 10 94.20 High High
Disease 55 94.16 High High
Obesity 1 93.52 High High
Diabetes Mellitus 1 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (high) of Gene_expression (expression) of ACE in liver associated with cancer, colon cancer and metastasis
1) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.74 Pain Relevance 0
A significant increase in ACE mRNA expression was observed at day 5 in the tumor-bearing liver compared to sham livers (P = 0.0412), indicating an effect of tumor induction.
Positive_regulation (increase) of Gene_expression (expression) of ACE mRNA in liver associated with cancer
2) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.27 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (converted) of Gene_expression (expression) of ACE in liver associated with cancer, colon cancer and metastasis
3) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.81 Pain Relevance 0
ACE and ACE2 expression in CRC liver metastases
Positive_regulation (liver) of Gene_expression (liver) of ACE in liver associated with colon cancer and metastasis
4) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.42 Pain Relevance 0
Our current results suggest a possible explanation for this, as the increased expression of ACE mRNA (and protein) at this time would require additional, or at least continued, captopril treatment to ensure sustained inhibition of ACE activity.


Positive_regulation (increased) of Gene_expression (expression) of ACE mRNA
5) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 0.66 Pain Relevance 0
ACE mRNA expression was higher in CRC metastases compared to the surrounding liver at day 16 (P = 0.0007) and was increased markedly at day 21 by captopril treatment; captopril treated CRC metastases had significantly higher ACE expression compared control CRC metastases (P = 0.0001) (Figure 2) as well as to the surrounding liver (P = 0.0001).
Positive_regulation (higher) of Gene_expression (expression) of ACE mRNA in liver associated with colon cancer and metastasis
6) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.54 Pain Relevance 0
This increase in ACE expression would need to be taken into consideration if targeting ACE in anti-cancer therapies.
Positive_regulation (increase) of Gene_expression (expression) of ACE associated with cancer
7) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.43 Pain Relevance 0
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (elevated) of Gene_expression (expression) of ACE in kidney associated with renal disease
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.88 Pain Relevance 0.17
An uncontrolled retrospective study showed that echocardiographic parameters, including left ventricular ejection fraction, fractional shortening, and sphericity index, in DMD and BMD patients improved 3 years after administration of either ACE inhibitors alone or the combination of both ACE-inhibitors and ?
Positive_regulation (improved) of Gene_expression (combination) of ACE associated with duchenne muscular dystrophy and muscular dystrophy
9) Confidence 0.16 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 1.27 Pain Relevance 0.16
For example, there are several studies which, using genetic or chemical inactivation of ACE in vivo, suggest that the enzyme does not have a substantial physiological role to play in the degradation of A?
Positive_regulation (inactivation) of Gene_expression (in vivo) of ACE
10) Confidence 0.14 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.34 Pain Relevance 0.03

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