INT26786

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Context Info
Confidence 0.34
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.37
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
neurons 2
nerve 1
dermis 1
cortex 1
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 87 99.80 Very High Very High Very High
Dopamine 4 98.60 Very High Very High Very High
Neurotransmitter 11 97.76 Very High Very High Very High
GABAergic 21 92.72 High High
Glutamate 7 91.60 High High
Eae 4 85.36 High High
antagonist 19 80.24 Quite High
medulla 28 77.16 Quite High
agonist 21 76.72 Quite High
vaginimus 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 30 100.00 Very High Very High Very High
Obesity 57 89.00 High High
Anorexia 14 81.16 Quite High
Sleep Disorders 2 68.12 Quite High
Convulsion 1 64.80 Quite High
Increased Venous Pressure Under Development 3 60.88 Quite High
Targeted Disruption 5 50.00 Quite Low
Dyspareunia 4 50.00 Quite Low
Sprains And Strains 6 44.56 Quite Low
Weight Gain 4 10.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two types of labelled cells are detected in sections of rat and mouse striata processed for in situ hybridization histochemistry with 35S-radiolabelled RNA probes complementary to the messenger RNA (mRNA) encoding glutamic acid decarboxylase (GAD), the synthesis enzyme for gamma-aminobutyric acid (GABA): numerous lightly, and fewer very densely labelled neurons.
Positive_regulation (encoding) of GAD in neurons associated with gaba and generalized anxiety disorder
1) Confidence 0.34 Published 1989 Journal Brain Res. Section Abstract Doc Link 2568874 Disease Relevance 0.18 Pain Relevance 0.08
The levels of glutamic acid decarboxylase (GAD) were strongly increased in the cortex and the striatum in dopamine D2 receptors null (D2R-/-) mice, which show a significant locomotor impairment.
Positive_regulation (increased) of GAD in cortex associated with dopamine and generalized anxiety disorder
2) Confidence 0.25 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080900 Disease Relevance 0.16 Pain Relevance 0.32
CONCLUSIONS: It is concluded that the increase of PGP 9.5 immunoreactive nerve fibres, in patients with vulvodynia, may be either secondary to nerve sprouting, or may represent neural hyperplasia.
Positive_regulation (increase) of PGP 9.5 in nerve
3) Confidence 0.21 Published 2003 Journal Br. J. Dermatol. Section Body Doc Link 12786836 Disease Relevance 0 Pain Relevance 0
RESULTS: There was a statistically significant increase of density and number of PGP 9.5 immunoreactive in the papillary dermis of patients with vulvodynia of the vestibulitis type, compared with those of controls.
Positive_regulation (increase) of PGP 9.5 in dermis
4) Confidence 0.21 Published 2003 Journal Br. J. Dermatol. Section Body Doc Link 12786836 Disease Relevance 0 Pain Relevance 0
Indeed, most HA neurons contain the GABA-synthesizing enzyme GAD and GABA itself (see Haas and Panula, 2003 for review).
Positive_regulation (enzyme) of GAD in neurons associated with gaba and generalized anxiety disorder
5) Confidence 0.11 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.29 Pain Relevance 0.44
GAD activity measurements
Positive_regulation (measurements) of GAD associated with generalized anxiety disorder
6) Confidence 0.06 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.20 Pain Relevance 0.05
GAD is the enzyme necessary to produce GABA, although GABA is not thought to inhibit the NPY/AgRP neurones and its exact function is unknown at present.
Positive_regulation (necessary) of GAD associated with gaba and generalized anxiety disorder
7) Confidence 0.05 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.43

General Comments

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