INT267875
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Thus, SNC80-induced phosphorylation of DOR-eGFP likely contributes to receptor desensitization, a phenomenon not observed after ARM390 treatment. | |||||||||||||||
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Finally SNC80 but not AR-M100390 produced DOR-eGFP phosphorylation, suggesting that the two agonists produce distinct active receptor conformations in vivo which likely lead to differential receptor trafficking.
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Considering this scenario, we observed that SNC80 but not ARM390 produced DOR-eGFP phosphorylation on the Ser363 site. | |||||||||||||||
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Hence, SNC80 triggered DOR-eGFP phosphorylation, uncoupling and endocytosis, while none of these events occurred with ARM390. | |||||||||||||||
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(i.e phosphorylation at Tyr216 residue) in the SNc of MPTP-treated mice. | |||||||||||||||
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The difference in the ability of SNC80 and ARM390 to produce phosphorylation at this site, likely accounts for the divergent internalization profiles of these two drugs. | |||||||||||||||
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General Comments
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