INT267875

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.69
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
SNc 1
St13 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 290 98.96 Very High Very High Very High
opioid receptor 35 95.44 Very High Very High Very High
Analgesic 25 93.92 High High
Substantia nigra 4 90.00 High High
analgesia 10 75.12 Quite High
Opioid 20 75.00 Quite High
IPN 40 74.20 Quite High
Pain 70 70.96 Quite High
allodynia 20 64.16 Quite High
Delta opioid receptors 15 58.00 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 40 99.84 Very High Very High Very High
Death 37 98.00 Very High Very High Very High
Targeted Disruption 31 95.80 Very High Very High Very High
Disease 23 92.80 High High
Inflammatory Pain 40 74.20 Quite High
Pain 75 70.96 Quite High
Neuropathic Pain 20 64.16 Quite High
Neuroblastoma 15 56.88 Quite High
Hyperalgesia 25 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, SNC80-induced phosphorylation of DOR-eGFP likely contributes to receptor desensitization, a phenomenon not observed after ARM390 treatment.
Phosphorylation (phosphorylation) of SNC80
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.17
Finally SNC80 but not AR-M100390 produced DOR-eGFP phosphorylation, suggesting that the two agonists produce distinct active receptor conformations in vivo which likely lead to differential receptor trafficking.


Phosphorylation (phosphorylation) of SNC80 associated with agonist
2) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2672171 Disease Relevance 0.25 Pain Relevance 0.92
Considering this scenario, we observed that SNC80 but not ARM390 produced DOR-eGFP phosphorylation on the Ser363 site.
Phosphorylation (phosphorylation) of SNC80
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.09
Hence, SNC80 triggered DOR-eGFP phosphorylation, uncoupling and endocytosis, while none of these events occurred with ARM390.
Phosphorylation (phosphorylation) of SNC80
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.17
(i.e phosphorylation at Tyr216 residue) in the SNc of MPTP-treated mice.
Phosphorylation (phosphorylation) of SNc in SNc associated with parkinson's disease
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.01 Pain Relevance 0.04
The difference in the ability of SNC80 and ARM390 to produce phosphorylation at this site, likely accounts for the divergent internalization profiles of these two drugs.
Phosphorylation (phosphorylation) of SNC80
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox