INT267875

Context Info Confidence 0.12 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.69 Pain Relevance 1.55

unfolded protein binding (St13) protein folding (St13) cytosol (St13) protein complex (St13) cytoplasm (St13)

Anatomy Link Frequency SNc 1 St13 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 290 98.96 opioid receptor 35 95.44 Analgesic 25 93.92 Substantia nigra 4 90.00 analgesia 10 75.12 Opioid 20 75.00 IPN 40 74.20 Pain 70 70.96 allodynia 20 64.16 Delta opioid receptors 15 58.00

Disease Link Frequency Relevance Heat Parkinson's Disease 40 99.84 Death 37 98.00 Targeted Disruption 31 95.80 Disease 23 92.80 Inflammatory Pain 40 74.20 Pain 75 70.96 Neuropathic Pain 20 64.16 Neuroblastoma 15 56.88 Hyperalgesia 25 5.00 Stress 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, SNC80-induced phosphorylation of DOR-eGFP likely contributes to receptor desensitization, a phenomenon not observed after ARM390 treatment.

Phosphorylation (phosphorylation) of SNC80

1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.17

Finally SNC80 but not AR-M100390 produced DOR-eGFP phosphorylation, suggesting that the two agonists produce distinct active receptor conformations in vivo which likely lead to differential receptor trafficking.

Phosphorylation (phosphorylation) of SNC80 associated with agonist

2) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2672171 Disease Relevance 0.25 Pain Relevance 0.92

Considering this scenario, we observed that SNC80 but not ARM390 produced DOR-eGFP phosphorylation on the Ser363 site.

Phosphorylation (phosphorylation) of SNC80

3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.09

Hence, SNC80 triggered DOR-eGFP phosphorylation, uncoupling and endocytosis, while none of these events occurred with ARM390.

Phosphorylation (phosphorylation) of SNC80

4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.17

(i.e phosphorylation at Tyr216 residue) in the SNc of MPTP-treated mice.

Phosphorylation (phosphorylation) of SNc in SNc associated with parkinson's disease

5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.01 Pain Relevance 0.04

The difference in the ability of SNC80 and ARM390 to produce phosphorylation at this site, likely accounts for the divergent internalization profiles of these two drugs.

Phosphorylation (phosphorylation) of SNC80

6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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