INT26788

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 93
Total Number 95
Disease Relevance 27.05
Pain Relevance 42.71

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mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 13
striatum 9
substantia nigra 8
prefrontal 4
globus pallidus 3
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 785 100.00 Very High Very High Very High
Dopamine 331 100.00 Very High Very High Very High
Glutamate 270 100.00 Very High Very High Very High
Enkephalin 185 100.00 Very High Very High Very High
substance P 115 100.00 Very High Very High Very High
Dynorphin 94 100.00 Very High Very High Very High
projection neuron 60 100.00 Very High Very High Very High
Neuropeptide 57 100.00 Very High Very High Very High
Somatostatin 38 100.00 Very High Very High Very High
Cholecystokinin 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 414 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Sprains And Strains 2 99.92 Very High Very High Very High
Cold Sores 26 99.84 Very High Very High Very High
Targeted Disruption 13 99.78 Very High Very High Very High
Dyskinesias 274 99.60 Very High Very High Very High
Parkinson's Disease 259 99.56 Very High Very High Very High
Headache 2 99.50 Very High Very High Very High
Neuropathic Pain 109 99.44 Very High Very High Very High
Disease 309 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal glutamic acid decarboxylase (GAD67) and enkephalin expressions were increased in the striatum ipsilateral to the lesion.
Gene_expression (expressions) of glutamic acid decarboxylase in striatum associated with enkephalin
1) Confidence 0.78 Published 1999 Journal Neuroreport Section Abstract Doc Link 10549811 Disease Relevance 0.07 Pain Relevance 0.28
Changes in striatal neuropeptides and GAD67 expression following a minimal cortical lesion.
Gene_expression (expression) of GAD67 associated with neuropeptide and enkephalin
2) Confidence 0.78 Published 1999 Journal Neuroreport Section Title Doc Link 10549811 Disease Relevance 0.07 Pain Relevance 0.42
Striatal glutamic acid decarboxylase (GAD67) and enkephalin expressions were increased in the striatum ipsilateral to the lesion.
Gene_expression (expressions) of GAD67 in striatum associated with enkephalin
3) Confidence 0.78 Published 1999 Journal Neuroreport Section Abstract Doc Link 10549811 Disease Relevance 0.07 Pain Relevance 0.28
Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression.
Gene_expression (expression) of GAD67 gene associated with gaba and agonist
4) Confidence 0.78 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.05
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum.
Gene_expression (expression) of glutamic acid decarboxylase in striatum associated with dopamine receptor, gabaergic, enkephalin and substance p
5) Confidence 0.78 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 0.80
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum.
Gene_expression (expression) of GAD67 in striatum associated with dopamine receptor, gabaergic, enkephalin and substance p
6) Confidence 0.78 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 0.80
It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
Gene_expression (expression) of GAD67 mRNA in output neurons associated with gaba receptor, enkephalin and substance p
7) Confidence 0.78 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7535410 Disease Relevance 0 Pain Relevance 1.01
The results show that L-DOPA-induced dyskinesia is associated with overexpression of PDyn and GAD67 mRNA in the striatal projection neurons, and GAD67 mRNA levels in the globus pallidus.
Gene_expression (overexpression) of GAD67 mRNA in globus pallidus associated with projection neuron and dyskinesias
8) Confidence 0.77 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.51 Pain Relevance 0.12
In view of previous results after 6-hydroxydopamine lesions in adults, it appears that the behavioral differences observed after adult or neonatal 6-hydroxydopamine lesions are accompanied by a similar alteration of GAD67, preproenkephalin and dopamine D2 receptor gene expression in presumed striatal projection neurons.
Gene_expression (expression) of GAD67 in projection neurons associated with dopamine and projection neuron
9) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.42
The present study demonstrates that bilateral 6-hydroxydopamine lesions of dopamine neurons in neonate rats are able to induce a long-term and widespread alteration in the expression of genes encoding for GAD67, preproenkephalin and dopamine D2 receptor in the striatum.
Gene_expression (expression) of GAD67 in dopamine neurons associated with dopamine
10) Confidence 0.77 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.49
We used in situ hybridization histochemistry to assess expression of dopamine receptors (D1R, D2R and D3R), neurotensin, proenkephalin and glutamate decarboxylase-67 (GAD67) in the prefrontal cortex, striatum, and/or nucleus accumbens in adult rats with neonatal ventral hippocampal (VH) lesions and in control animals after acute and chronic treatment with antipsychotic drugs clozapine and haloperidol.
Gene_expression (expression) of GAD67 in prefrontal associated with nucleus accumbens, glutamate and dopamine receptor
11) Confidence 0.76 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.15 Pain Relevance 0.22
We used in situ hybridization histochemistry to assess expression of dopamine receptors (D1R, D2R and D3R), neurotensin, proenkephalin and glutamate decarboxylase-67 (GAD67) in the prefrontal cortex, striatum, and/or nucleus accumbens in adult rats with neonatal ventral hippocampal (VH) lesions and in control animals after acute and chronic treatment with antipsychotic drugs clozapine and haloperidol.
Gene_expression (expression) of proenkephalin and glutamate decarboxylase-67 in prefrontal associated with nucleus accumbens, glutamate and dopamine receptor
12) Confidence 0.76 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.14 Pain Relevance 0.22
Second, this part roughly corresponds to "area 1" defined by Okada et al. [52] in which small neurons expressing VGLUT2 and GAD67 are localized, allowing comparison with a limited and defined group of cNTS neurons.
Gene_expression (expressing) of GAD67 in neurons
13) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.08 Pain Relevance 0.13
A total loss of neurons expressing glutamate decarboxylase (GAD67), enkephalin or substance P mRNA was observed on a similar circular area, suggesting degeneration of the two populations of striatal efferent neurons.
Gene_expression (expressing) of GAD67 in efferent neurons associated with glutamate, enkephalin and substance p
14) Confidence 0.75 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406933 Disease Relevance 0.10 Pain Relevance 0.50
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Gene_expression (expression) of GAD67 in neurons
15) Confidence 0.75 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates.
Gene_expression (expression) of GAD67 in neurons associated with glutamate and enkephalin
16) Confidence 0.75 Published 1999 Journal Synapse Section Title Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.36
Striatal expression of preproenkephalin and preprodynorphin mRNAs, subthalamic cytochrome oxidase mRNA, and glutamate decarboxylase 67 mRNA in the pars reticulata of the substantia nigra was measured by in-situ hybridization.
Gene_expression (expression) of glutamate decarboxylase 67 mRNA in substantia nigra associated with glutamate and substantia nigra
17) Confidence 0.73 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19712101 Disease Relevance 0.33 Pain Relevance 0.10
The 33G10.17 cells transfected with the GAD67 gene expressed GAD67 protein and synthesized low levels of GABA at permissive temperature (33 degrees C), when the cells were proliferating, and increased GAD67 and GABA during differentiation at nonpermissive temperature (39 degrees C) in vitro, because GAD67 protein expression was upregulated with differentiation.
Gene_expression (expression) of GAD67 associated with gaba
18) Confidence 0.72 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10338278 Disease Relevance 0.73 Pain Relevance 1.07
The 33G10.17 cells transfected with the GAD67 gene expressed GAD67 protein and synthesized low levels of GABA at permissive temperature (33 degrees C), when the cells were proliferating, and increased GAD67 and GABA during differentiation at nonpermissive temperature (39 degrees C) in vitro, because GAD67 protein expression was upregulated with differentiation.
Gene_expression (expressed) of GAD67 associated with gaba
19) Confidence 0.72 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10338278 Disease Relevance 0.44 Pain Relevance 0.85
We used quantitative double-label in situ hybridization to examine in rat brain the expression of NMDAR1, NMDAR2A, NMDAR2B, and NMDAR2C mRNA in six neurochemically defined populations of striatal neurons: preproenkephalin (ENK) and preprotachykinin (SP) expressing projection neurons, and somatostatin (SOM), glutamic acid decarboxylase 67 (GAD67), parvalbumin (PARV), and choline acetyltransferase (ChAT) expressing interneurons.
Gene_expression (expression) of glutamic acid decarboxylase 67 in interneurons associated with somatostatin and projection neuron
20) Confidence 0.72 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9889300 Disease Relevance 0 Pain Relevance 0.34

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