INT267894

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 9.71
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ITK) signal transduction (ITK) cytoplasm (ITK)
Anatomy Link Frequency
lens capsule 2
LEC 2
embryos 1
extracellular matrix 1
ITK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 31 96.96 Very High Very High Very High
fibrosis 2 95.64 Very High Very High Very High
COX-2 inhibitor 101 88.68 High High
Inflammation 28 86.48 High High
corticosteroid 9 85.76 High High
diclofenac 22 80.12 Quite High
cINOD 11 74.32 Quite High
palliative 3 63.72 Quite High
cva 4 55.12 Quite High
methotrexate 9 53.16 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 33 99.84 Very High Very High Very High
Cancer 299 98.40 Very High Very High Very High
Pathologic Processes 2 98.12 Very High Very High Very High
Capsule Opacification 603 97.44 Very High Very High Very High
Cataract 317 97.44 Very High Very High Very High
Internal Fibrosis 2 95.88 Very High Very High Very High
Apoptosis 160 94.36 High High
Endophthalmitis 18 90.24 High High
Retina Disease 27 88.84 High High
Macular Edema 18 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, unlike in the EMT system of the U.S., in Japan there is only one level of EMT, and on-the-job training or continuing education is not required.8

The Nara Incidents

Gene_expression (system) of EMT
1) Confidence 0.57 Published 2008 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2672251 Disease Relevance 0.34 Pain Relevance 0.03
However, unlike in the EMT system of the U.S., in Japan there is only one level of EMT, and on-the-job training or continuing education is not required.8

The Nara Incidents

Gene_expression (system) of EMT
2) Confidence 0.57 Published 2008 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2672251 Disease Relevance 0.40 Pain Relevance 0.03
We have discovered cataractous LEC that have undergone EMT express COX-2 mRNA and protein, but normal LEC do not.
Gene_expression (express) of EMT
3) Confidence 0.19 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 1.11 Pain Relevance 0.05
Increasing evidence links overexpression of COX-2 to EMT during embryonic development, fetal implantation, and tumor formation and invasion [8,28-30].
Gene_expression (overexpression) of EMT associated with cancer
4) Confidence 0.19 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 1.05 Pain Relevance 0.38
Preliminary data obtained in our laboratory indicate that LEC undergoing EMT, have increased expression of estrogen and higher levels of aromatase activity compared to normal LEC [67].
Gene_expression (undergoing) of EMT
5) Confidence 0.17 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.67 Pain Relevance 0.09
Taken together, these results indicated COX-2 expression was upregulated in LEC undergoing EMT.


Gene_expression (undergoing) of EMT
6) Confidence 0.17 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.38 Pain Relevance 0
Moreover, even after one week of culture in the absence of drug, the LEC did not regain the ability to adhere to the lens capsule and proliferate and undergo EMT (Figure 11A-D).
Gene_expression (proliferate) of EMT in lens capsule
7) Confidence 0.17 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.12 Pain Relevance 0
In support of other studies, this data provides evidence that EMT-like changes occur in canine LEC.


Gene_expression (changes) of EMT-like
8) Confidence 0.17 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.14 Pain Relevance 0
Markers of EMT, such as lumican, Snail, Slug, and COX-2 were expressed in LEC.
Gene_expression (expressed) of EMT in LEC
9) Confidence 0.15 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2765474 Disease Relevance 1.20 Pain Relevance 0.09
To ensure that EMT-like changes were occurring in LEC, real-time RT-PCR was used to examine expression of EMT markers.
Spec (examine) Gene_expression (expression) of EMT in LEC
10) Confidence 0.15 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2765474 Disease Relevance 0.82 Pain Relevance 0.04
Using real-time RT-PCR, we examined the expression of markers of EMT-like changes in our canine LEC scratch model.
Spec (examined) Gene_expression (expression) of EMT-like
11) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0 Pain Relevance 0
The aim of this study was to assess expression of pAkt in LEC undergoing EMT and to determine the effect of inhibiting signal transduction through Akt on PCO formation in an ex vivo canine lens capsule explant model.
Gene_expression (undergoing) of EMT in lens capsule associated with capsule opacification
12) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.61 Pain Relevance 0.03
Postoperatively, the primary response of the remaining LEC is to undergo EMT, proliferate, and increase production of aberrant extracellular matrix proteins.
Gene_expression (production) of EMT in extracellular matrix
13) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.37 Pain Relevance 0
According to this essential role of Snail1 in the modulation of EMT, expression of this factor has been associated to several pathological processes, such as tumour invasion [3] and renal fibrosis [4].
Gene_expression (expression) of EMT associated with fibrosis, pathologic processes, cancer and internal fibrosis
14) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.51 Pain Relevance 0.05
Among them, an essential role for Snail1 has been highlighted by the general induction of the expression of this gene during EMT in many cell lines and especially by the lack of E-cadherin down-regulation during gastrulation of Snail1 deficient murine embryos [3].
Gene_expression (expression) of EMT in embryos
15) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680015 Disease Relevance 0.89 Pain Relevance 0.03
We show here that SNAI1-associated EMT is present in OSCC and potentially contributes to tumor progression in at least a subset of tumors.
Gene_expression (present) of EMT associated with cancer and skin cancer
16) Confidence 0.08 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 1.10 Pain Relevance 0.10

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