INT26795

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 44
Total Number 45
Disease Relevance 27.66
Pain Relevance 8.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
neurons 5
platelet 3
pituitary 2
cartilage 2
myocardium 1
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 459 100.00 Very High Very High Very High
cytokine 250 99.92 Very High Very High Very High
ischemia 15 99.92 Very High Very High Very High
COX-2 inhibitor 6 99.72 Very High Very High Very High
Substantia nigra 18 99.68 Very High Very High Very High
chemokine 56 99.04 Very High Very High Very High
Inflammatory mediators 12 98.90 Very High Very High Very High
medulla 7 98.48 Very High Very High Very High
Arthritis 556 98.40 Very High Very High Very High
metalloproteinase 67 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 532 100.00 Very High Very High Very High
Cancer 121 100.00 Very High Very High Very High
Cv Unclassified Under Development 18 99.92 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.92 Very High Very High Very High
Injury 256 99.68 Very High Very High Very High
Ulcers 56 99.64 Very High Very High Very High
Fever 1 99.52 Very High Very High Very High
Apoptosis 670 99.50 Very High Very High Very High
Nicotine Addiction 100 99.46 Very High Very High Very High
Diabetic Retinopathy 4 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review specifically highlights some of the evidence of sex steroid regulation of growth factor expression.
Gene_expression (expression) of growth factor
1) Confidence 0.62 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18394805 Disease Relevance 0.63 Pain Relevance 0.37
This may be linked to the generation of transforming growth factor in inflammation, which can stimulate bone formation, and to the molecular composition of entheses where molecules are present, such as the proteoglycan aggrecan, that are normally found in cartilage.
Gene_expression (generation) of growth factor in cartilage associated with inflammation
2) Confidence 0.44 Published 1998 Journal Am. J. Med. Sci. Section Abstract Doc Link 9766483 Disease Relevance 0.62 Pain Relevance 0.48
In conclusion, after an ACS, levels of myotrophin are more informative at predicting MACE than NTproBNP and may be useful to risk stratify patients.
Gene_expression (levels) of myotrophin
3) Confidence 0.29 Published 2007 Journal Clin. Sci. Section Abstract Doc Link 17014419 Disease Relevance 0.33 Pain Relevance 0.06
In addition, these data indicate that OGF is an autocrine produced growth factor that is related to the emergence of vascular architecture and the maintenance of homeostasis in blood vessels.
Gene_expression (produced) of growth factor in blood vessels
4) Confidence 0.22 Published 1998 Journal Dev. Dyn. Section Abstract Doc Link 9566952 Disease Relevance 0 Pain Relevance 0.42
We have previously observed sexually dimorphic expression of the growth factor, neuregulin 1 (NRG1) following L5 nerve root ligation (LR) in male and female rats.
Gene_expression (expression) of growth factor in nerve
5) Confidence 0.12 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17459743 Disease Relevance 0.07 Pain Relevance 0.31
Expression of the myofibroblastic marker alpha-smooth muscle actin, connective tissue growth factor, and ET-1 itself in PSC was reduced, while expression of matrix metalloproteinase-9 was enhanced.
Gene_expression (Expression) of growth factor in PSC associated with primary sclerosing cholangitis and metalloproteinase
6) Confidence 0.10 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612819 Disease Relevance 1.29 Pain Relevance 0.30
Ulcer healing involves expression of various growth factors including hepatocyte growth factor (HGF) at the ulcer margin and the rise in plasma gastrin but the effects of locally applied HGF and gastrin, which are known to act as trophic factors for the gastric mucosa, with or without neutralizing antibodies against HGF and gastrin or COX-1 and COX-2 inhibitors on ulcer healing and the expression of cyclooxygenase (COX)-1 and COX-2 during this healing have been little studied.
Gene_expression (expression) of growth factor in hepatocyte associated with ulcers and cox-2 inhibitor
7) Confidence 0.08 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 0.49 Pain Relevance 0.04
OBJECTIVES: Magnetic fields have been shown to affect cell proliferation and growth factor expression in cultured cells.
Gene_expression (expression) of growth factor
8) Confidence 0.07 Published 2000 Journal Cardiovasc. Res. Section Abstract Doc Link 10728432 Disease Relevance 0 Pain Relevance 0.36
Each growth factor and specific antibodies against HGF and gastrin (100 ng/100 microl each) were injected just around the ulcer immediately after ulcer induction and this local application was repeated at day 2 following anesthesia and laparotomy.
Gene_expression (injected) of growth factor in HGF associated with anesthesia and ulcers
9) Confidence 0.07 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11192947 Disease Relevance 0.94 Pain Relevance 0.18
In skeletal muscle, an increased expression of insulin like growth factor-I isoforms IGF-IEa and mechano-growth factor (MGF) combined with downregulation of myostatin is thought to be essential for training-induced hypertrophy.
Gene_expression (expression) of mechano-growth factor in skeletal muscle associated with hypertrophy
10) Confidence 0.07 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17038487 Disease Relevance 0.10 Pain Relevance 0.09
We tested various cytokines such as Ang II, tumor necrosis factor alpha, interferon gamma, tumor growth factor beta and platelet derived growth factor (data not shown).
Gene_expression (beta) of growth factor in platelet associated with necrosis, cancer and cytokine
11) Confidence 0.07 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.35 Pain Relevance 0.05
Furthermore, GDNF, another growth factor whose expression is also upregulated after nerve injury can activate ERK in cultured DRG neurons [15].
Gene_expression (expression) of growth factor in neurons associated with nervous system injury
12) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.34 Pain Relevance 0.13
This indicates that growth factor function is growth factor specific in DRG-neurons.


Gene_expression (function) of growth factor in neurons
13) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.32 Pain Relevance 0.24
Further evidence of hypoxia is suggested by the increases in vascular endothelial growth factor (VEGF) expression in patients with diabetic retinopathy [3–5] and retinopathy of prematurity (ROP) [6], because VEGF is known to be a hypoxia-inducible gene [7,8].
Gene_expression (expression) of growth factor associated with hypoxia, diabetic retinopathy and retinopathy
14) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 2.08 Pain Relevance 0.03
It shows that most changes in growth factor expression were significant with regard to the corresponding controls, which have been treated with PMA only.


Gene_expression (expression) of growth factor
15) Confidence 0.04 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0 Pain Relevance 0.23
Apoptosis of neurons is caused by growth factor deprivation, ischemia, hyperthermia, hypercalcemia, excitotoxin, and active free radicals (6, 7).
Gene_expression (deprivation) of growth factor in neurons associated with ischemia, hypercalcemia, fever and apoptosis
16) Confidence 0.03 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782166 Disease Relevance 1.74 Pain Relevance 0.17
The first growth factors identified on this basis were transforming growth factor (TGF)-?
Gene_expression (transforming) of growth factor
17) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.20 Pain Relevance 0
Later, the pituitary also proved to be the source of another very important growth factor, vascular endothelial growth factor (VEGF) (44).


Gene_expression (source) of growth factor in pituitary
18) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.10 Pain Relevance 0.11
To determine the neurotrophic or growth factor(s) that would be most effective in protecting TPS neurons from apoptosis, and could potentially maintain the initial regenerative response, we analyzed surface receptor and growth factor expression profiles (Figure 4B).
Spec (analyzed) Gene_expression (expression) of growth factor in neurons associated with apoptosis
19) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.80 Pain Relevance 0.04
The up-regulation in the expression of genes for several growth factor receptors during the first week post-SCI also suggest that administration of these factors may protect TPS neurons from cell death and maintain a regenerative response, but only if given during the early period after injury.



Gene_expression (expression) of growth factor in neurons associated with spinal cord injury, injury and death
20) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2894843 Disease Relevance 0.87 Pain Relevance 0.09

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