INT267969

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV1) small molecule metabolic process (AGT) aging (AGT)
extracellular matrix organization (AGT) lipid metabolic process (TRPV1) cell-cell signaling (AGT)
Anatomy Link Frequency
heart 1
AGT (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 57.52 Quite High
headache 3 44.16 Quite Low
Onset of action 1 16.40 Low Low
ischemia 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 43 95.00 High High
Cv Unclassified Under Development 3 90.72 High High
Increased Venous Pressure Under Development 6 79.24 Quite High
Cardiovascular Disease 1 56.12 Quite High
Pressure And Volume Under Development 8 44.72 Quite Low
Headache 3 44.16 Quite Low
Heart Rate Under Development 5 43.04 Quite Low
Renal Artery Obstruction 3 5.00 Very Low Very Low Very Low
Renal Disease 3 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Valsartan, like all ARBs, acts by inhibiting the binding of angiotensin II to the AT1-subtype of angiotensin II receptor. 17,18 A hallmark of blockers of the renin-angiotensin system is their ability to lower blood pressure without usually inducing a reflex increase in sympathetic nerve activity, which is reflected by the absence of consistent changes in heart rate.19,20 After oral administration, the peak plasma concentration of valsartan is reached after 3 hours, and the elimination half-life is 6 hours.
angiotensin II Binding (binding) of AT1-subtype in heart
1) Confidence 0.00 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 0.44 Pain Relevance 0.08

General Comments

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