INT267973

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.67
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB, ESR1) nucleoplasm (ESR1) enzyme binding (ESR1)
DNA binding (ESR1) protein complex (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
muscle 1
CHKB (Homo sapiens)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 92.92 High High
alcohol 1 75.24 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhabdomyolysis 8 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 4 100.00 Very High Very High Very High
Muscle Disease 10 98.46 Very High Very High Very High
Cramps 1 93.76 High High
Myalgia 2 92.92 High High
Hypersensitivity 1 86.48 High High
Liver Failure 1 84.92 Quite High
Jaundice 1 83.48 Quite High
Hepatitis 1 83.08 Quite High
Liver Disease 1 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinically important myopathy is characterized by muscle symptoms and evidence of muscle damage (elevated CK levels), which in its most severe form, rhabdomyolysis, has more extensive muscle damage and is usually associated with renal impairment.24 In the 912 subjects in the ER niacin–simvastatin Simcor® clinical trial database, no cases of myopathy, rhabdomyolysis, or CK elevations >10 times the upper limit of normal were reported over a period as long as 52 weeks (Table 2).
CK Binding (associated) of ER in muscle associated with disorders of creatine metabolism, rhabdomyolysis and muscle disease
1) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672455 Disease Relevance 1.67 Pain Relevance 0.13

General Comments

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