INT267994

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
neuronal 2
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 94.08 High High
Inflammation 2 50.56 Quite High
Paracetamol 1 33.48 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 94.08 High High
Coronary Heart Disease 1 78.44 Quite High
Increased Venous Pressure Under Development 2 74.32 Quite High
Myocardial Infarction 12 68.92 Quite High
INFLAMMATION 2 50.56 Quite High
Stroke 1 45.76 Quite Low
Shock 1 45.68 Quite Low
Toxicity 1 33.84 Quite Low
Stress 22 29.12 Quite Low
Disease 2 28.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects were not seen in endothelial NOS deficient mice, suggesting a role for neuronal NOS preventing XO inhibition of cardiac excitation-contraction coupling.80 The finding that allopurinol is a potent myofilament Ca2+ sensitizer, particularly in the setting of ischemia, is thought to be due to the inhibition of basal XO production.
Positive_regulation (role) of Negative_regulation (inhibition) of XO in neuronal associated with ischemia
1) Confidence 0.33 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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