INT267994

Context Info Confidence 0.33 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0.07

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH) peroxisome (XDH) cytoplasm (XDH)

Anatomy Link Frequency neuronal 2 XDH (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 2 94.08 Inflammation 2 50.56 Paracetamol 1 33.48 antagonist 2 5.00 fibrosis 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 2 94.08 Coronary Heart Disease 1 78.44 Increased Venous Pressure Under Development 2 74.32 Myocardial Infarction 12 68.92 INFLAMMATION 2 50.56 Stroke 1 45.76 Shock 1 45.68 Toxicity 1 33.84 Stress 22 29.12 Disease 2 28.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects were not seen in endothelial NOS deficient mice, suggesting a role for neuronal NOS preventing XO inhibition of cardiac excitation-contraction coupling.80 The finding that allopurinol is a potent myofilament Ca2+ sensitizer, particularly in the setting of ischemia, is thought to be due to the inhibition of basal XO production.

Positive_regulation (role) of Negative_regulation (inhibition) of XO in neuronal associated with ischemia

1) Confidence 0.33 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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