INT267995

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.77
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
neuronal 2
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 98.84 Very High Very High Very High
ischemia 2 94.08 High High
Inflammation 4 49.68 Quite Low
Paracetamol 1 32.60 Quite Low
alcohol 3 28.28 Quite Low
Arthritis 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 77 96.24 Very High Very High Very High
Cv Unclassified Under Development 2 94.08 High High
Renal Disease 7 83.24 Quite High
Hyperuricemia 33 82.76 Quite High
Coronary Heart Disease 1 77.56 Quite High
Increased Venous Pressure Under Development 3 73.44 Quite High
Myocardial Infarction 12 68.04 Quite High
INFLAMMATION 3 49.68 Quite Low
Stroke 1 45.76 Quite Low
Shock 1 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects were not seen in endothelial NOS deficient mice, suggesting a role for neuronal NOS preventing XO inhibition of cardiac excitation-contraction coupling.80 The finding that allopurinol is a potent myofilament Ca2+ sensitizer, particularly in the setting of ischemia, is thought to be due to the inhibition of basal XO production.
Negative_regulation (preventing) of Negative_regulation (inhibition) of XO in neuronal associated with ischemia
1) Confidence 0.30 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.31 Pain Relevance 0.05
Distinguishing between serum urate overproducing and underexcreting gout patients may have therapeutic significance but does not need to be routinely performed.15 Concomitant use of colchicine or NSAIDs during the initiation of urate-lowering may be needed to prevent rebound flares.11,16

Xanthine oxidase inhibitors

Negative_regulation (prevent) of Negative_regulation (inhibitors) of Xanthine oxidase associated with cinod and crystal associated disease
2) Confidence 0.16 Published 2010 Journal Core evidence Section Body Doc Link PMC2899777 Disease Relevance 0.46 Pain Relevance 0.10

General Comments

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