INT267996

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 94.38 High High
Inflammation 8 92.24 High High
tolerance 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 31 100.00 Very High Very High Very High
Targeted Disruption 29 99.76 Very High Very High Very High
Toxicity 1 94.56 High High
Wound Healing 24 92.48 High High
INFLAMMATION 8 92.24 High High
Colitis 1 90.10 High High
Cataract 40 84.08 Quite High
Injury 19 81.52 Quite High
Uveitis 1 65.88 Quite High
Stress 52 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further evidence for a possible direct antioxidant effect of allopurinol comes from models of experimental colitis where tungsten (a potent XO inhibitor) failed to improve symptoms whereas allopurinol did.69 Augustin et al suggested that this direct effect was only seen at higher doses.70 This was also seen in mice paracetamol toxicity models where lower doses (sufficient to block XO activity) of allopurinol failed to show antioxidant protection but higher doses did.71 There have been other non-XO effects of allopurinol suggested such as copper chelation, preventing LDL oxidation as described above,72 inhibition of heat shock protein (hsp) expression73 and calcium sensitization (below).
Negative_regulation (inhibition) of hsp associated with colitis, toxicity, paracetamol and shock
1) Confidence 0.42 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.61 Pain Relevance 0.14
After these peaks, the Hsp levels decreased gradually.
Negative_regulation (decreased) of Hsp
2) Confidence 0.05 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.16 Pain Relevance 0
Since past studies have predominantly dealt with Hsp 70, these experiments were conducted to confirm our previous conclusions, using the Hsp 70.1 knockout mouse.
Negative_regulation (using) of Hsp associated with targeted disruption
3) Confidence 0.05 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.74 Pain Relevance 0

General Comments

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