INT267997

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
plaques 2
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 61.96 Quite High
fibrosis 1 15.28 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 3 99.84 Very High Very High Very High
Atherosclerotic Plaque 1 93.92 High High
Myocardial Infarction 12 92.90 High High
Injury 1 79.00 Quite High
Coronary Artery Disease 3 63.88 Quite High
Cv Unclassified Under Development 2 61.96 Quite High
Metabolic Syndrome 1 56.00 Quite High
Diabetes Mellitus 2 47.92 Quite Low
Hypertension 2 46.32 Quite Low
Hypertrophy 1 16.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this, the activity of endothelial bound XO is increased by more than 200% in patients with CHF.36 Furthermore, studies using electron spin resonance have demonstrated that endothelial oxygen tension is thought to regulate XO activity at a post-translational level as demonstrated by a doubling in XOR activity post exposure to hypoxia without any increase in mRNA expression for 24 hours in bovine aortic endothelial cells.37 Cells produce a marked elevation in XO levels when exposed to ischemia38 and XDH conversion to XO is also accelerated in hypoxia.39 When infused acutely, XO produces a marked decrease in cardiac contractility, cardiac index and left ventricular systolic pressure.40 In atherosclerotic plaques, urate levels are found to be elevated six-fold, reflecting accelerated purine oxidation within these plaques.
Positive_regulation (accelerated) of Positive_regulation (elevation) of XO in plaques associated with atherosclerotic plaque, hypoxia and myocardial infarction
1) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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