INT267997

Context Info Confidence 0.35 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.83 Pain Relevance 0.03

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH) peroxisome (XDH) cytoplasm (XDH)

Anatomy Link Frequency plaques 2 XDH (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 2 61.96 fibrosis 1 15.28 Inflammation 2 5.00 antagonist 2 5.00 Paracetamol 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 3 99.84 Atherosclerotic Plaque 1 93.92 Myocardial Infarction 12 92.90 Injury 1 79.00 Coronary Artery Disease 3 63.88 Cv Unclassified Under Development 2 61.96 Metabolic Syndrome 1 56.00 Diabetes Mellitus 2 47.92 Hypertension 2 46.32 Hypertrophy 1 16.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Despite this, the activity of endothelial bound XO is increased by more than 200% in patients with CHF.36 Furthermore, studies using electron spin resonance have demonstrated that endothelial oxygen tension is thought to regulate XO activity at a post-translational level as demonstrated by a doubling in XOR activity post exposure to hypoxia without any increase in mRNA expression for 24 hours in bovine aortic endothelial cells.37 Cells produce a marked elevation in XO levels when exposed to ischemia38 and XDH conversion to XO is also accelerated in hypoxia.39 When infused acutely, XO produces a marked decrease in cardiac contractility, cardiac index and left ventricular systolic pressure.40 In atherosclerotic plaques, urate levels are found to be elevated six-fold, reflecting accelerated purine oxidation within these plaques.

Positive_regulation (accelerated) of Positive_regulation (elevation) of XO in plaques associated with atherosclerotic plaque, hypoxia and myocardial infarction

1) Confidence 0.35 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.83 Pain Relevance 0.03

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