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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (XDH, Nos1) cytosol (XDH, Nos1) mitochondrion (Nos1)
small molecule metabolic process (XDH) peroxisome (XDH) enzyme binding (Nos1)
Anatomy Link Frequency
reticulum 1
XDH (Homo sapiens)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2 63.36 Quite High
Inflammation 2 62.68 Quite High
Paracetamol 1 45.60 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 95.28 Very High Very High Very High
Increased Venous Pressure Under Development 2 93.22 High High
Myocardial Infarction 12 90.52 High High
Cv Unclassified Under Development 2 63.36 Quite High
INFLAMMATION 2 62.68 Quite High
Shock 1 57.80 Quite High
Toxicity 1 45.96 Quite Low
Colitis 1 37.04 Quite Low
Uveitis 1 22.72 Low Low
Stroke 1 20.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In dogs with pacing-induced heart failure, allopurinol improved myocardial contractility and eff iciency in oxygen utilization, prevented increases in systemic vasoconstriction and ameliorated reductions in myocardial contractility.65,76,77 In murine post-ischemic cardiomyopathy models, allopurinol attenuated the increase in end-systolic and end-diastolic volumes,78 increased survival, augmented ventricular function as well as reduced products of lipid peroxidation.79 Khan et al found a direct protein-protein interaction between XO and neuronal NOS in the sarcoplasmic reticulum of cardiac myocytes.80 Allopurinol improved myofilament calcium sensitivity as contraction force increased without a concomitant rise in systolic Ca2+ influx.
XO Binding (interaction) of neuronal NOS in reticulum associated with coronary heart disease, increased venous pressure under development and myocardial infarction
1) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672460 Disease Relevance 0.46 Pain Relevance 0.06

General Comments

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