INT268007

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.38
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf8) extracellular space (Fgf8) extracellular region (Fgf8)
Anatomy Link Frequency
embryos 4
ectoderm 1
mesoderm 1
neural 1
Fgf8 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 41 93.56 High High
Dopamine 83 90.84 High High
chemokine 2 68.72 Quite High
Ventromedial thalamus 1 42.60 Quite Low
Thalamus 14 40.44 Quite Low
Action potential 15 8.88 Low Low
imagery 13 7.20 Low Low
anesthesia 13 5.00 Very Low Very Low Very Low
tetrodotoxin 8 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 165 98.60 Very High Very High Very High
Apoptosis 116 97.44 Very High Very High Very High
Congenital Anomalies 45 85.40 High High
Nervous System Malformation 1 80.12 Quite High
Neurodegenerative Disease 8 74.56 Quite High
Persistent Truncus Arteriosus 24 37.92 Quite Low
Cleft Palate 48 12.32 Low Low
Ventricular Heart Septal Defects 24 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, ectopic expression of Fgf8 in either the subplate or cortical plate further revealed that thalamocortical axons (TCAs) are responsive to guidance cues present in both the subplate and cortical plate [26].
Gene_expression (expression) of Fgf8
1) Confidence 0.72 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2672616 Disease Relevance 0 Pain Relevance 0
Because fgf8 expression was essentially normal in Spry1;Wnt1-Cre embryos, fgf8 availability is likely not a factor in decreased NCC survival.
Gene_expression (expression) of fgf8 in embryos
2) Confidence 0.62 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.46 Pain Relevance 0
We noticed that expression of some FGF members (e.g., FGF8 and FGF9) was up-regulated during early neural induction from hiPSC as well hESC (Figure 1C), which led us to evaluate the role of the FGF pathway during neural induction from hiPSC.
Gene_expression (expression) of FGF8 in neural
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
This data rules out the possibility that changes in fgf8 expression or availability account for the decrease in proliferation seen in the first arch of Spry1;Wnt1-Cre embryos (Figure 5C).


Gene_expression (expression) of fgf8 in embryos
4) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.12 Pain Relevance 0.05
To determine whether fgf8 expression was altered in Spry1;Wnt1-Cre embryos through a cell non-autonomous mechanism, we performed whole mount in situ hybridization with an fgf8 riboprobe (Figure 7).
Spec (whether) Gene_expression (expression) of fgf8 in embryos
5) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.15 Pain Relevance 0.03
Fgf8 expression is maintained in Spry1-expressing transgenic mice
Gene_expression (expression) of Fgf8 associated with targeted disruption
6) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
These data indicate that fgf8 expression remains intact in E10.5 Spry1;Wnt-Cre embryos when compared to their litter mate controls.
Gene_expression (expression) of fgf8 in embryos
7) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.14 Pain Relevance 0.04
Fgf8 expression in the ectoderm of the first and second branchial arch is induced by Shh signals from the foregut endoderm [7,25-27].
Gene_expression (expression) of Fgf8 in ectoderm
8) Confidence 0.56 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
Nonetheless the introduction of FGF10 to chick embryos up-regulated FGF8 expression in the ectoderm through Wnt3a signaling and stimulated SHH expression in the posterior mesoderm followed by outgrowth initiation of chick limb structures [48], [49].
Gene_expression (expression) of FGF8 in mesoderm
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.15 Pain Relevance 0.35

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