INT268009

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 0.23
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpsm2) nucleus (Gpsm2) cytoplasm (Gpsm2)
Anatomy Link Frequency
eye 4
cortex 2
neurons 1
Gpsm2 (Mus musculus)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 3 99.02 Very High Very High Very High
Serotonin 108 97.28 Very High Very High Very High
monoamine 6 96.32 Very High Very High Very High
Glutamate 5 85.60 High High
withdrawal 3 70.80 Quite High
Raphe 12 65.96 Quite High
tetrodotoxin 99 65.28 Quite High
sodium channel 3 18.08 Low Low
Thalamus 50 5.00 Very Low Very Low Very Low
fluoxetine 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Miosis 1 98.48 Very High Very High Very High
Aids-related Complex 16 67.36 Quite High
Adhesions 6 63.92 Quite High
Blindness 1 33.60 Quite Low
Handedness 36 24.72 Low Low
Retina Disease 9 10.40 Low Low
Ganglion Cysts 30 5.00 Very Low Very Low Very Low
Vibrio Infection 15 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution patterns of presynaptic markers in the dLGN after ME
Gene_expression (after) of dLGN
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0.04
Our results clearly showed that ME induces the rearrangement of retinogeniculate projections in the mouse dLGN even after eye-specific segregation is mostly complete, and that there is a critical period for this rearrangement.
Gene_expression (induces) of dLGN in eye
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.07 Pain Relevance 0.17
This result suggests that the imbalance of visual inputs between the two eyes is not sufficient for changing RGC projection patterns in the mouse dLGN after eye-specific segregation is mostly complete.
Gene_expression (projection) of dLGN in eye
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0.12
It was unclear how rapidly the rearrangement of retinogeniculate projections occurs in response to ME, to what extent retinogeniculate projections can expand in the dLGN, and whether there are any preferential directions in which RGC axons extend in response to ME.
Gene_expression (expand) of dLGN
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0.06
We next addressed whether retinogeniculate projections in the dLGN preferentially expand in any specific directions in response to ME.
Gene_expression (projections) of dLGN
5) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
The recovery of the dLGN projection to visual cortex, in spite of previous occupation of this territory by VB axons suggests that dLGN axons have an advantage in the innervation of that particular cortical area.
Gene_expression (projection) of dLGN in cortex
6) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2672616 Disease Relevance 0 Pain Relevance 0
NT-3 has been shown to be most strongly expressed in presumptive visual cortex (V1) from around P0 [34], while its receptor TrkC, is selectively expressed by neurons in the dLGN.
Gene_expression (expressed) of dLGN in neurons
7) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2672616 Disease Relevance 0.06 Pain Relevance 0.04
A model to explain this would be that dLGN axons and presumptive visual cortex express some matching label(s) that confer this advantage.
Gene_expression (axons) of dLGN in cortex
8) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2672616 Disease Relevance 0 Pain Relevance 0
28×28 for those mRGCs projecting to the dLGN (at most half of the total population of mRGCs), then acuity would be ?
Gene_expression (projecting) of dLGN
9) Confidence 0.29 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2998442 Disease Relevance 0.10 Pain Relevance 0
Supporting this theory, mice lacking another component of the machinery, the 5HT1B receptor, also show defects in eye-specific segregation in the LGN and SC (Upton et al, 1999).
Gene_expression (segregation) of LGN in eye
10) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.18
Genetically modified mice lacking monoamine oxidase A, an enzyme that breaks down serotonin, exhibit severe disruptions in the barrels domains of the primary somatosensory cortex (Rebsam et al, 2002) as well as in eye-specific segregation in the dLGN and SC (Upton et al, 1999).
Gene_expression (segregation) of dLGN in eye associated with primary somatosensory cortex, serotonin and monoamine
11) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.51
AC1 has an important function in the refinement of the ipsilateral retinal projection in both the LGN and the SC, acting presynaptically in RGCs to modulate the reshaping of axon terminal arbors in the retinofugal projections and not affecting axon guidance in the travelling of retinal fibres to the targets (Ravary et al, 2003; Plas et al, 2004; Nicol et al, 2006, 2007).
Gene_expression (projection) of LGN
12) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.21

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