INT268022

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
neurons 2
Pde5a (Rattus norvegicus)
Kcnj5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 3 50.00 Quite Low
Spinal nerve ligature 11 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Neuropathic pain 7 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Neuronal excitability 3 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Nervous System Injury 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Natriuresis 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that endogenous NO, possibly produced by nNOS in DRG neurons, does not affect basal KATP channel activity in either SS or SNL neurons.

8-Br-cGMP activates KATP channels, but fails to mimic completely the activation induced by NO

cGMP Positive_regulation (activates) of Gene_expression (channels) of KATP in neurons
1) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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