INT268024

Context Info Confidence 0.14 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.07

ATPase activity (Abcc8) plasma membrane (Abcc8) transmembrane transport (Abcc8)

Anatomy Link Frequency neurons 1 Abcc8 (Rattus norvegicus) Kcnj5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal nerve ligature 34 66.08 Pain 18 50.00 potassium channel 3 50.00 addiction 1 49.52 nMDA receptor 1 32.20 Neuropathic pain 15 5.00 Hyperalgesia 13 5.00 anesthesia 5 5.00 Neurotransmitter 5 5.00 isoflurane 5 5.00

Disease Link Frequency Relevance Heat Natriuresis 1 10.52 Neuropathic Pain 18 5.00 Nervous System Injury 17 5.00 Hyperalgesia 15 5.00 Injury 7 5.00 Death 6 5.00 Pain 6 5.00 Nociception 5 5.00 Hypoxia 3 5.00 Ganglion Cysts 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previous studies using mutagenesis have revealed that thiol-reagents modify KATP channel activity by interacting with a single cysteine residue at either Kir6.2 or SUR1.

SUR1 Binding (interacting) of KATP

1) Confidence 0.14 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0

In neurons pre-incubated with anti-SUR1 antibody, excised patch recordings also showed KATP channel activity (Fig. 3D and 3E), but the blocking effect of glybenclamide, which binds to the SUR1 subunit, was significantly suppressed compared to that in the absence of the anti-SUR1 antibody (Fig. 3G).

SUR1 subunit Binding (binds) of KATP in neurons

2) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.