INT268024

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc8) plasma membrane (Abcc8) transmembrane transport (Abcc8)
Anatomy Link Frequency
neurons 1
Abcc8 (Rattus norvegicus)
Kcnj5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 34 66.08 Quite High
Pain 18 50.00 Quite Low
potassium channel 3 50.00 Quite Low
addiction 1 49.52 Quite Low
nMDA receptor 1 32.20 Quite Low
Neuropathic pain 15 5.00 Very Low Very Low Very Low
Hyperalgesia 13 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 1 10.52 Low Low
Neuropathic Pain 18 5.00 Very Low Very Low Very Low
Nervous System Injury 17 5.00 Very Low Very Low Very Low
Hyperalgesia 15 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies using mutagenesis have revealed that thiol-reagents modify KATP channel activity by interacting with a single cysteine residue at either Kir6.2 or SUR1.
SUR1 Binding (interacting) of KATP
1) Confidence 0.14 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
In neurons pre-incubated with anti-SUR1 antibody, excised patch recordings also showed KATP channel activity (Fig. 3D and 3E), but the blocking effect of glybenclamide, which binds to the SUR1 subunit, was significantly suppressed compared to that in the absence of the anti-SUR1 antibody (Fig. 3G).
SUR1 subunit Binding (binds) of KATP in neurons
2) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0.07

General Comments

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