INT268027

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neurons 2
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 70 100.00 Very High Very High Very High
ketamine 94 98.48 Very High Very High Very High
spinal dorsal horn 12 83.76 Quite High
glial activation 3 82.72 Quite High
Neuropathic pain 94 77.48 Quite High
allodynia 35 63.56 Quite High
Spinal cord 39 50.00 Quite Low
Analgesic 23 50.00 Quite Low
potassium channel 3 50.00 Quite Low
Dorsal horn 20 39.08 Quite Low
Disease Link Frequency Relevance Heat
Injury 31 100.00 Very High Very High Very High
Neuropathic Pain 138 77.48 Quite High
Spinal Injuries 1 65.32 Quite High
Nervous System Injury 28 50.00 Quite Low
Ganglion Cysts 33 32.48 Quite Low
Pain 19 5.00 Very Low Very Low Very Low
Hyperalgesia 14 5.00 Very Low Very Low Very Low
Nociception 9 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If the SNL injury down regulates some of the gene expression including CK1?
Regulation (regulates) of Gene_expression (injury) of SNL associated with injury
1) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.37
g/kg) alone significantly down-regulated pNR1 expression at 2 h after administration compared with that of SNL-Saline group (Fig 2, P < 0.05).
Regulation (regulated) of Gene_expression (expression) of SNL associated with spinal nerve ligature
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.14 Pain Relevance 0.86
In these experiments, zaprinast had no effect on KATP channel activity either in control neurons (n = 5; p = 0.88 vs. baseline), or in SNL neurons (n = 4; p = 1.0 vs. baseline) (data not shown).


Neg (no) Regulation (effect) of Gene_expression (neurons) of SNL in neurons
3) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0

General Comments

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