INT268029

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.23
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kcnj11) endoplasmic reticulum (Kcnj11) plasma membrane (Kcnj11)
neurological system process (Kcnj11)
Anatomy Link Frequency
neurons 2
Kcnj11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 12 75.00 Quite High
Spinal nerve ligature 44 71.44 Quite High
Hyperalgesia 28 68.52 Quite High
nMDA receptor 4 58.80 Quite High
Neuropathic pain 28 49.76 Quite Low
Pain 36 43.88 Quite Low
Neurotransmitter 8 38.60 Quite Low
Analgesic 12 5.00 Very Low Very Low Very Low
Neuronal excitability 12 5.00 Very Low Very Low Very Low
analgesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 32 91.60 High High
Nociception 16 69.68 Quite High
Hyperalgesia 32 68.52 Quite High
Neuropathic Pain 36 49.76 Quite Low
Death 16 40.48 Quite Low
Natriuresis 4 37.12 Quite Low
Pain 20 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As in native KATP channels, we showed that NO directly activates cloned SUR1/Kir6.2 channels expressed in COS7 cells, although this effect is approximately 3-fold less potent than in native channels.
Gene_expression (expressed) of Kir6
1) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0.03
Compared to SUR1/Kir6.2 expressed in DRG neurons [57], the decreased sensitivity of channels in COS7 cells to NO may reflect differences in technique (inside-out recordings from cloned channels, cell-attached from native KATP channels), or variations in the redox status of the cytosolic environment, and different protein conformation in the two experimental models.
Gene_expression (expressed) of Kir6 in neurons
2) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0.03
Specifically, current through recombinant wild-type SUR1/Kir6.2 channels expressed in COS7 cells was activated by NO, but channels formed only from truncated isoform Kir6.2 subunits without SUR1 subunits were insensitive to NO.
Gene_expression (expressed) of Kir6
3) Confidence 0.02 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2673211 Disease Relevance 0.14 Pain Relevance 0.24
To determine the site of action of NO on KATP channels, we investigated the effect of SNAP in inside-out recordings from cloned SUR1/Kir6.2 channels, the predominant KATP channel in DRG neurons [57], heterologously expressed in COS7 cells.
Gene_expression (expressed) of Kir6 in neurons
4) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.09 Pain Relevance 0

General Comments

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