INT268031

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc8) plasma membrane (Abcc8) transmembrane transport (Abcc8)
Anatomy Link Frequency
neuronal 1
neurons 1
Abcc8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 34 98.80 Very High Very High Very High
Pain 18 50.00 Quite Low
potassium channel 3 50.00 Quite Low
Neuropathic pain 15 5.00 Very Low Very Low Very Low
Hyperalgesia 13 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 17 83.64 Quite High
Neuropathic Pain 18 5.00 Very Low Very Low Very Low
Hyperalgesia 15 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test whether the binding target of the anti-SUR1 antibody was part of the actual channel in the neuronal plasmalemmal membrane, and specifically on the regulatory SUR1 subunit, we obtained single channel recordings from excised membrane patches, using the inside-out configuration of the patch-clamp technique, after adding anti-SUR1 antibody in the bath at 37°C for 120 min.
Spec (whether) Regulation (target) of SUR1 in neuronal
1) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0.10
We first investigated whether the effect of NO on cloned SUR1/Kir6.2 mimicked the NO effect on native KATP channels in large DRG neurons.
Spec (whether) Regulation (effect) of SUR1 in neurons
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.08 Pain Relevance 0

General Comments

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