INT268040

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc8) plasma membrane (Abcc8) transmembrane transport (Abcc8)
Abcc8 (Rattus norvegicus)
Abcc8 - C717S (2)
Pain Link Frequency Relevance Heat
nMDA receptor 5 59.68 Quite High
potassium channel 15 50.00 Quite Low
Spinal nerve ligature 55 5.00 Very Low Very Low Very Low
Pain 45 5.00 Very Low Very Low Very Low
Neuropathic pain 35 5.00 Very Low Very Low Very Low
Hyperalgesia 35 5.00 Very Low Very Low Very Low
Analgesic 15 5.00 Very Low Very Low Very Low
Neuronal excitability 15 5.00 Very Low Very Low Very Low
analgesia 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 40 67.00 Quite High
Natriuresis 5 41.84 Quite Low
Neuropathic Pain 45 5.00 Very Low Very Low Very Low
Hyperalgesia 40 5.00 Very Low Very Low Very Low
Pain 25 5.00 Very Low Very Low Very Low
Death 20 5.00 Very Low Very Low Very Low
Nociception 20 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Ganglion Cysts 5 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequent addition of SNAP 1 mM into the bath significantly activated SUR1/Kir6.2 channels (n = 7, p < 0.001) in a concentration-dependent fashion (Figure 8B).
Positive_regulation (activated) of SUR1
1) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.07 Pain Relevance 0
Similar to the response of wild type SUR1/Kir6.2 channels, bath application of 1 mM SNAP significantly activated the SUR1-C717S/Kir6.2 channel in the presence of 1 mM [ATP]i.
Positive_regulation (activated) of SUR1 (C717S)
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
SNAP-induced SUR1-C717S/Kir6.2 channel activation was reversed by DTT (5 mM) (n = 7).
Positive_regulation (induced) of SUR1 (C717S)
3) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
Taken together, these novel findings prove that NO activates KATP channels via S-nitrosylation of one or more cysteine residues on the SUR1 subunit (Figure 10).
Positive_regulation (activates) of SUR1
4) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
As in native KATP channels, we showed that NO directly activates cloned SUR1/Kir6.2 channels expressed in COS7 cells, although this effect is approximately 3-fold less potent than in native channels.
Positive_regulation (activates) of SUR1
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0.03

General Comments

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