INT268066

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.13
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
liver 2
anterior-posterior 1
dorsal-ventral 1
dentate gyrus 1
hepatocytes 1
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 2 99.78 Very High Very High Very High
cytokine 20 74.60 Quite High
Inflammation 14 74.24 Quite High
Hippocampus 98 71.16 Quite High
depression 34 68.36 Quite High
Serotonin 41 45.36 Quite Low
fluoxetine 17 36.76 Quite Low
Eae 22 5.00 Very Low Very Low Very Low
gABA 21 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 164 94.48 High High
Anxiety Disorder 62 92.56 High High
INFLAMMATION 16 74.24 Quite High
Apoptosis 4 73.36 Quite High
Depression 36 68.36 Quite High
Colitis 2 60.56 Quite High
Schizophrenia 17 59.48 Quite High
Neurodegenerative Disease 68 50.00 Quite Low
Disease 12 33.12 Quite Low
Affective Disorder 7 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under basal conditions in mammals, Trp catabolism is mediated by tryptophan dioxygenase (TDO) activation - mainly in the liver - which is controlled by GCs [22], [27].
Regulation (controlled) of tryptophan dioxygenase in liver
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.76 Pain Relevance 0.11
Under basal conditions in mammals, Trp catabolism is mediated by tryptophan dioxygenase (TDO) activation - mainly in the liver - which is controlled by GCs [22], [27].
Regulation (controlled) of TDO in liver
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.75 Pain Relevance 0.11
Administration of glucocorticoids to rats results in elevations of the tryptophan-metaboliting enzymes and TPH in vivo and that administration of dexamethasone phosphate regulates TDO activity in cells from control and adrenarectomized mice, respectively [38,39].
Regulation (regulates) of TDO associated with dexamethasone
3) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.81 Pain Relevance 0.08
In addition, glucocorticoids regulate either or both the activity and mRNA levels of TDO in rat liver [40] and isolated primary hepatocytes [41,42].
Regulation (regulate) of TDO in hepatocytes
4) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.81 Pain Relevance 0.07
In mice heterozygous for the alpha-isoform of calcium/calmodulin-dependent protein kinase II, in which dentate gyrus granule cells fail to mature normally, TDO immunoreactivity was substantially downregulated in the dentate gyrus granule cells.
Regulation (immunoreactivity) of TDO in dentate gyrus
5) Confidence 0.24 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.04
Almost uniform TDO immunoreactivity was detected along the anterior-posterior and dorsal-ventral axes (Fig. 10).


Regulation (immunoreactivity) of TDO in dorsal-ventral
6) Confidence 0.24 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Almost uniform TDO immunoreactivity was detected along the anterior-posterior and dorsal-ventral axes (Fig. 10).


Regulation (immunoreactivity) of TDO in anterior-posterior
7) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0

General Comments

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