INT268068

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.08
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
granule cells 6
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 9 66.44 Quite High
GABAergic 5 47.60 Quite Low
gABA 35 44.80 Quite Low
Hippocampus 126 39.20 Quite Low
midbrain 4 37.92 Quite Low
fluoxetine 26 5.00 Very Low Very Low Very Low
depression 17 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
antidepressant 13 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 79.16 Quite High
Neurodegenerative Disease 69 50.00 Quite Low
Anxiety Disorder 29 50.00 Quite Low
Congenital Anomalies 7 21.64 Low Low
Schizophrenia 17 5.00 Very Low Very Low Very Low
Depression 17 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 10 5.00 Very Low Very Low Very Low
Immunization 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the expression of TDO was remarkably downregulated in the granule cells of CaMKII?
Negative_regulation (downregulated) of Gene_expression (expression) of TDO in granule cells
1) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
+/- mice, the decreased expression of TDO may be due to the lack of mature granule cells in CaMKII?
Negative_regulation (decreased) of Gene_expression (expression) of TDO in granule cells
2) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Reduced TDO expression in the granule cells of CaMKII?
Negative_regulation (Reduced) of Gene_expression (expression) of TDO in granule cells
3) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
We then examined whether levels of the major Trp metabolites kynurenine (Kyn) and kynurenic acid (KYNA) were reduced by tdo deletion, on the basis that the marked elevation of Trp in Tdo-/- mice suggested the insufficient compensatory conversion of Trp to formylkynurenine by IDO.
Spec (whether) Negative_regulation (reduced) of Gene_expression (deletion) of tdo
4) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.08 Pain Relevance 0.03
The expression level of TDO in the DG of CaMKII?
Negative_regulation (level) of Gene_expression (expression) of TDO
5) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
We next examined the expression of TDO in mature cells using CaMKII?
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of TDO
6) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0

General Comments

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