INT268069

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph2)
Tph2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 83.44 Quite High
midbrain 4 81.72 Quite High
medulla 4 71.16 Quite High
Raphe 16 66.24 Quite High
depression 8 57.60 Quite High
Serotonin 7 50.00 Quite Low
Pain 1 24.68 Low Low
Neurotransmitter 2 21.04 Low Low
Eae 10 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 30 78.64 Quite High
Depression 8 57.60 Quite High
Neurodegenerative Disease 19 50.00 Quite Low
Schizophrenia 2 44.32 Quite Low
Aggression 1 43.12 Quite Low
Autism 3 42.16 Quite Low
Mental Disorders 6 41.36 Quite Low
Alcohol Addiction 1 41.28 Quite Low
Disease 3 26.08 Quite Low
Pain 1 24.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data showed that 5-HT level in Lmx1b iCKO mice was reduced to 60% of control mice probably due to down-regulation of Tph2.
Regulation (regulation) of Tph2
1) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.10
Given the notion that tryptophan hydroxylase (TPH) is the rate-limiting enzyme for 5-HT biosynthesis, we asked whether the level or activity of tph2 would be modulated by TDO deletion.
Spec (whether) Regulation (modulated) of tph2
2) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.26 Pain Relevance 0.18

General Comments

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