INT268072

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 4 66.44 Quite High
Hippocampus 16 43.52 Quite Low
midbrain 4 42.24 Quite Low
Eae 10 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 79.16 Quite High
Anxiety Disorder 29 50.00 Quite Low
Neurodegenerative Disease 19 50.00 Quite Low
Congenital Anomalies 2 21.64 Low Low
Depression 7 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Tourette's Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then examined whether levels of the major Trp metabolites kynurenine (Kyn) and kynurenic acid (KYNA) were reduced by tdo deletion, on the basis that the marked elevation of Trp in Tdo-/- mice suggested the insufficient compensatory conversion of Trp to formylkynurenine by IDO.
Spec (whether) Negative_regulation (reduced) of Positive_regulation (elevation) of Tdo
1) Confidence 0.43 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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