INT268074

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
plasma 2
T cell 2
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 19 81.52 Quite High
Hippocampus 16 58.96 Quite High
midbrain 4 57.68 Quite High
cytokine 10 55.64 Quite High
Inflammation 7 55.28 Quite High
depression 14 51.52 Quite High
Eae 11 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 82 97.84 Very High Very High Very High
Anxiety Disorder 31 94.00 High High
Neurodegenerative Disease 19 93.52 High High
INFLAMMATION 8 55.28 Quite High
Apoptosis 2 54.40 Quite High
Sepsis 2 53.84 Quite High
Injury 2 53.04 Quite High
Depression 15 51.52 Quite High
Schizophrenia 4 49.44 Quite Low
Colitis 1 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mice had markedly increased plasma levels of Trp, 5-HIAA, ILA and IAA in the presence of IDO, demonstrating that the accumulation of Trp and acceleration of serotonergic and transamination pathways are largely dependent on TDO (Figure 1 and 2).
Positive_regulation (dependent) of Positive_regulation (accumulation) of TDO in plasma
1) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.26 Pain Relevance 0.06
It was demonstrated that increased tryptophan depletion via the IDO1 pathway increases the generation of kynurenines (see Fig. 1) which inhibit T cell responses and cause the development of dendritic cells with tolerogenic properties [22], [27].
Positive_regulation (increases) of Positive_regulation (increased) of tryptophan in T cell
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.48 Pain Relevance 0.16

General Comments

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