INT268077

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
T cell 2
neural 2
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 19 79.04 Quite High
cytokine 10 55.64 Quite High
Inflammation 7 55.28 Quite High
depression 14 49.40 Quite Low
Hippocampus 16 22.08 Low Low
Eae 11 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 82 97.84 Very High Very High Very High
Neurodegenerative Disease 19 84.96 Quite High
INFLAMMATION 8 55.28 Quite High
Apoptosis 2 54.40 Quite High
Sepsis 2 51.36 Quite High
Injury 2 50.56 Quite High
Anxiety Disorder 31 50.00 Quite Low
Depression 15 49.40 Quite Low
Schizophrenia 4 46.96 Quite Low
Colitis 1 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings demonstrate that the loss of TDO induces the proliferation of both neural progenitors and neural stem cells in the SVZ, and hence might contribute, either fully or partly, to a decrease in the size of the LV.


Positive_regulation (induces) of Negative_regulation (loss) of TDO in neural
1) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.19 Pain Relevance 0
It was demonstrated that increased tryptophan depletion via the IDO1 pathway increases the generation of kynurenines (see Fig. 1) which inhibit T cell responses and cause the development of dendritic cells with tolerogenic properties [22], [27].
Positive_regulation (increased) of Negative_regulation (depletion) of tryptophan in T cell
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.43 Pain Relevance 0.13

General Comments

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