INT268080

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.41
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
liver 2
hilus 1
cerebellum 1
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 3 61.88 Quite High
gABA 21 59.08 Quite High
depression 20 54.96 Quite High
Hippocampus 98 51.00 Quite High
antidepressant 12 37.52 Quite Low
Serotonin 11 25.52 Quite Low
Eae 20 5.00 Very Low Very Low Very Low
fluoxetine 17 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 75.84 Quite High
Congenital Anomalies 7 72.16 Quite High
Neurodegenerative Disease 68 72.00 Quite High
Anxiety Disorder 58 70.64 Quite High
Mental Disorders 6 61.32 Quite High
Autism 6 55.44 Quite High
Depression 20 54.96 Quite High
Tourette's Syndrome 4 54.48 Quite High
Disease 6 53.40 Quite High
Obesity 2 15.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The disruption of tdo was verified by the absence of tdo mRNA transcripts and TDO protein in the liver, as assessed by quantitative real-time PCR and Western blot analyses, respectively (Figure 1D and 1E).
Transcription (transcripts) of tdo in liver
1) Confidence 0.72 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.70 Pain Relevance 0.03
Granule cells in the cerebellum were immunoreactive for TDO, which is consistent with the relatively high expression of tdo mRNA in the cerebellum of the mice [12] (Fig. 7C).
Transcription (expression) of tdo in cerebellum
2) Confidence 0.72 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.09
The disruption of tdo was verified by the absence of tdo mRNA transcripts and TDO protein in the liver, as assessed by quantitative real-time PCR and Western blot analyses, respectively (Figure 1D and 1E).
Transcription (transcripts) of TDO protein in liver
3) Confidence 0.69 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.70 Pain Relevance 0.03
We also quantified the expression of tdo mRNA using real-time PCR.
Transcription (expression) of tdo
4) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Importantly, because the expression level of TDO in the interneurons of the wild-type hilus was similar to those in CaMKII?
Transcription (level) of TDO in hilus
5) Confidence 0.60 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0

General Comments

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