INT268081

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
brain 2
granule cells 2
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 98 73.08 Quite High
midbrain 8 64.16 Quite High
Serotonin 11 54.08 Quite High
gABA 21 5.00 Very Low Very Low Very Low
Eae 20 5.00 Very Low Very Low Very Low
depression 20 5.00 Very Low Very Low Very Low
fluoxetine 17 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 66.80 Quite High
Neurodegenerative Disease 68 50.00 Quite Low
Anxiety Disorder 58 50.00 Quite Low
Diphtheria 2 17.44 Low Low
Congenital Anomalies 7 9.28 Low Low
Depression 20 5.00 Very Low Very Low Very Low
Schizophrenia 13 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these results suggest that TDO expression gradually increased with the development of granule cells.
Positive_regulation (increased) of Gene_expression (expression) of TDO in granule cells
1) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0.04
TDO expression increased dramatically after 2 wk of age.
Positive_regulation (increased) of Gene_expression (expression) of TDO
2) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Assay for TDO activity
Positive_regulation (Assay) of Gene_expression (activity) of TDO
3) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0
Enhanced brain 5-HT synthesis in adult Tdo-/- mice
Positive_regulation (Enhanced) of Gene_expression (synthesis) of Tdo in brain
4) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.07 Pain Relevance 0.09
Spatial expression of TDO in the DG
Positive_regulation (Spatial) of Gene_expression (expression) of TDO
5) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0

General Comments

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