INT268082

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) signal transduction (Gpr35) oxidoreductase activity (Ido1)
plasma membrane (Gpr35) signal transducer activity (Gpr35) cytoplasm (Ido1)
Anatomy Link Frequency
plasma 1
brain 1
Ido1 (Mus musculus)
Gpr35 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 8 63.88 Quite High
Hippocampus 32 63.36 Quite High
Eae 20 5.00 Very Low Very Low Very Low
depression 14 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 58 50.00 Quite Low
Neurodegenerative Disease 38 50.00 Quite Low
Depression 14 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low
Tourette's Syndrome 4 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On this basis, IDO would be expected to decrease plasma and brain Trp levels but increase its downstream metabolites Kyn and KYNA [29].
IDO Positive_regulation (increase) of KYNA in brain
1) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.06
On this basis, IDO would be expected to decrease plasma and brain Trp levels but increase its downstream metabolites Kyn and KYNA [29].
IDO Positive_regulation (increase) of KYNA in plasma
2) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.06

General Comments

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