INT268085

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2, Tyrp1) pigmentation (Tyrp1)
Anatomy Link Frequency
plasma 2
Tdo2 (Mus musculus)
Tyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 4 77.96 Quite High
Hippocampus 16 19.36 Low Low
midbrain 4 18.08 Low Low
Eae 10 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 90.68 High High
Anxiety Disorder 29 50.00 Quite Low
Neurodegenerative Disease 19 50.00 Quite Low
Congenital Anomalies 2 33.16 Quite Low
Depression 7 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Tourette's Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings clearly demonstrated that TDO is indeed largely responsible for the systemic level of Trp, and that TDO contributes to Trp catabolites (5-HIAA, ILA, and IAA) levels in plasma, even in the presence of IDO.
TDO Regulation (responsible) of Gene_expression (level) of Trp in plasma
1) Confidence 0.25 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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