INT268131

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.09
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (MARCKS) plasma membrane (MARCKS) cytoplasm (MARCKS)
Anatomy Link Frequency
neurons 1
astrocytes 1
MARCKS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 130 100.00 Very High Very High Very High
Neuronal excitability 4 22.20 Low Low
Central nervous system 20 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 58 96.52 Very High Very High Very High
Heart Rate Under Development 8 93.84 High High
Virus Diseases 178 90.92 High High
Congenital Anomalies 4 88.32 High High
Targeted Disruption 28 86.76 High High
Borna Disease 8 50.00 Quite Low
Rabies Virus Infection 2 38.08 Quite Low
Ataxia 46 5.00 Very Low Very Low Very Low
Disease 38 5.00 Very Low Very Low Very Low
Cold Sores 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, MARCKS, the main PKC substrate, is also expressed in astrocytes [56].
Gene_expression (expressed) of MARCKS in astrocytes associated with kinase c
1) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.31 Pain Relevance 0.17
Likewise, we also demonstrated the restoration of phospho-MARCKS and phospho-SNAP25 levels in neurons infected with rBDV-LLSS, with levels being comparable to those observed in non-infected neurons following PKC stimulation (Figure 4C).
Gene_expression (levels) of phospho-MARCKS in neurons associated with kinase c
2) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.59 Pain Relevance 0.14
There are two studies where the entire human HPRT gene was expressed from such mammalian artificial chromosomes (MACs) [53, 54], using slightly different strategies but with the same results.
Gene_expression (expressed) of MACs
3) Confidence 0.17 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.18 Pain Relevance 0
The MACs obtained segregated accurately, they bound centromeric proteins, and they were about 1–5?
Gene_expression (obtained) of MACs
4) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0 Pain Relevance 0

General Comments

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