INT268144

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
upper 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 33.44 Quite Low
anesthesia 29 25.20 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 97.36 Very High Very High Very High
Creutzfeldt Jakob Disease 41 89.20 High High
Sprains And Strains 24 79.24 Quite High
Neurologic Manifestations 2 77.48 Quite High
Alzheimer's Dementia 40 67.44 Quite High
Lifespan 1 66.80 Quite High
Scrapie 27 54.08 Quite High
Infection 18 36.56 Quite Low
Targeted Disruption 25 29.20 Quite Low
Coronary Artery Disease 4 18.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, only a minority of PrPSc was localized in LE under these conditions similar to control cells (Figure 6A, upper panels, arrows).
Negative_regulation (minority) of Localization (localized) of PrPSc in upper
1) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.05 Pain Relevance 0
Indeed, when we blocked PrP exit from EEs the levels of PrPSc were drastically reduced and an accumulation of PrPC in EEs was observed (Figures 2A, 2C, 5A, 5B, S8B, S8C and S8D).
Negative_regulation (blocked) of Localization (exit) of PrP
2) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
Our results demonstrate that sPrPSc is transmissible and causes neurodegeneration in the absence of rPrPSc.
Negative_regulation (neurodegeneration) of Neg (absence) Localization (absence) of rPrPSc
3) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2809756 Disease Relevance 0.58 Pain Relevance 0

General Comments

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