INT26815

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Context Info
Confidence 0.46
First Reported 1987
Last Reported 2008
Negated 3
Speculated 1
Reported most in Abstract
Documents 15
Total Number 21
Disease Relevance 5.38
Pain Relevance 8.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OXT) extracellular space (OXT) extracellular region (OXT)
response to stress (OXT) cytoplasm (OXT)
Anatomy Link Frequency
plasma 7
cerebrospinal fluid 2
hypothalamus 1
bridge 1
OXT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 36 100.00 Very High Very High Very High
narcan 31 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Dismenorea 104 99.82 Very High Very High Very High
Nicotine 19 99.40 Very High Very High Very High
Somatostatin 17 98.32 Very High Very High Very High
Neuropeptide 130 98.00 Very High Very High Very High
agonist 40 97.88 Very High Very High Very High
Clonidine 16 97.36 Very High Very High Very High
Endogenous opioid 9 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 9 100.00 Very High Very High Very High
Dysmenorrhea 104 99.82 Very High Very High Very High
Emergencies 6 99.48 Very High Very High Very High
Nicotine Addiction 22 99.28 Very High Very High Very High
Premature Birth 17 92.00 High High
Pre-term Labor 21 86.68 High High
Lumbar Puncture Related Headaches 8 85.12 High High
Natriuresis 7 78.96 Quite High
Pressure And Volume Under Development 7 77.92 Quite High
Heart Rate Under Development 7 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings provide evidence that the effect of hypoglycemia on plasma OT levels is sensitive to the inhibition by SRIH and by naloxone-sensitive endogenous opioids.
Regulation (effect) of OT in plasma associated with hypoglycemia, endogenous opioid, narcan and somatostatin
1) Confidence 0.46 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2569658 Disease Relevance 0.35 Pain Relevance 1.03
The effects of the opioid antagonist naloxone on the vasopressin (AVP) and oxytocin (OT) responses to nicotine were studied in male non-smokers (21-30 years old).
Regulation (effects) of oxytocin associated with nicotine addiction, nicotine, antagonist, narcan and opioid
2) Confidence 0.44 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3214943 Disease Relevance 0.23 Pain Relevance 0.52
The effects of the opioid antagonist naloxone on the vasopressin (AVP) and oxytocin (OT) responses to nicotine were studied in male non-smokers (21-30 years old).
Regulation (effects) of OT associated with nicotine addiction, nicotine, antagonist, narcan and opioid
3) Confidence 0.39 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3214943 Disease Relevance 0.28 Pain Relevance 0.52
The treatment phases included: OT control, OT + barusiban, OT + atosiban, and OT + barusiban and then escalating high-dose OT rescue therapy (133–2000 mU kg-1 h-1).
Regulation (control) of OT
4) Confidence 0.26 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.13 Pain Relevance 0.17
Barusiban was particularly effective in maintaining low intrauterine pressure (IUP) near the end of pregnancy, which is when IUP in both OXT controls and fenoterol-treated females increased substantially.
Regulation (controls) of OXT associated with dismenorea
5) Confidence 0.24 Published 2006 Journal Biol. Reprod. Section Abstract Doc Link 16914691 Disease Relevance 0.92 Pain Relevance 0.59
Naloxone infusion for 60 min did not alter basal plasma AVP or OT levels.
Neg (not) Regulation (alter) of OT in plasma associated with narcan
6) Confidence 0.23 Published 1988 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3214943 Disease Relevance 0.42 Pain Relevance 0.65
We have investigated the effect of naloxone on the AVP and OT responses to hypertonic saline in man.
Regulation (responses) of OT associated with narcan
7) Confidence 0.23 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2605788 Disease Relevance 0 Pain Relevance 0.43
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of oxytocin in plasma associated with neuropeptide, agonist and clonidine
8) Confidence 0.22 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.15 Pain Relevance 0.41
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of OT in plasma associated with neuropeptide, agonist and clonidine
9) Confidence 0.19 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.16 Pain Relevance 0.41
OT control and fenoterol-treated monkeys delivered preterm (ca. day 154) and showed an increase in overall IUP.
Regulation (control) of OT associated with dismenorea
10) Confidence 0.11 Published 2007 Journal BMC Pregnancy Childbirth Section Abstract Doc Link PMC1892056 Disease Relevance 0.58 Pain Relevance 0.63
OT controls and the fenoterol group showed a marked IUP increase 4–5 days prior to delivery which occurred generally after 17 days of treatment.
Regulation (controls) of OT associated with dismenorea
11) Confidence 0.11 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.94 Pain Relevance 0.99
Previous studies in adult animals showed that hyperosmolality is a potent stimulus in the control of AVP and OT secretion [41-43].
Regulation (control) of OT
12) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.32 Pain Relevance 0.04
It is unknown however whether central cholinergic mechanisms have been developed in utero in the control of AVP and OT systems in the fetal hypothalamus.
Spec (whether) Regulation (control) of OT in hypothalamus
13) Confidence 0.08 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.16 Pain Relevance 0.26
Previous studies indicated that fetal plasma OT concentrations changed in sheep with the gestation age.
Regulation (changed) of OT in plasma
14) Confidence 0.08 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.06 Pain Relevance 0.06
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of oxytocin in cerebrospinal fluid associated with neuropeptide, agonist and clonidine
15) Confidence 0.07 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.15 Pain Relevance 0.41
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of OT in cerebrospinal fluid associated with neuropeptide, agonist and clonidine
16) Confidence 0.07 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.16 Pain Relevance 0.41
Central cholinergic signal-mediated neuroendocrine regulation of vasopressin and oxytocin in ovine fetuses

Background

Regulation (regulation) of oxytocin
17) Confidence 0.06 Published 2008 Journal BMC Dev Biol Section Title Doc Link PMC2570685 Disease Relevance 0.08 Pain Relevance 0.08
Combining the results of plasma AVP and OT changes following i.c.v. carbachol, we can get at least three preliminary conclusions: (1) the fetal hypothalamic OT system is functional intact at least at near-term; (2) central cholinergic signals play a role in the control of release of both AVP and OT from the fetal brain; and (3) the network or bridge between central cholinergic signals and the hypothalamic neuropeptide systems have been developed at 0.9 gestation in utero.
Regulation (changes) of OT in bridge associated with neuropeptide
18) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0.10 Pain Relevance 0.15
In the control group, i.c.v. injection of the vehicle did not change the maternal and fetal plasma AVP or OT levels.
Neg (not) Regulation (change) of OT in plasma
19) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
The responses of serum oxytocin (OT) and vasopressin (AVP) to the serotonergic HT1A agonist buspirone (15 mg p.o.) or the HTD1 agonist sumatriptan (6 mg injected subcutaneously) were evaluated in 7 normal men either in basal conditions or during an insulin (0.15 iu/kg as an i.v. bolus) tolerance test (ITT).
Regulation (responses) of serum oxytocin associated with sumatriptan, tolerance and agonist
20) Confidence 0.04 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8771561 Disease Relevance 0.19 Pain Relevance 0.56

General Comments

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