INT268161

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 7 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 18 74.40 Quite High
Sprains And Strains 10 64.40 Quite High
Scrapie 18 62.48 Quite High
Chronic Wasting Disease 6 60.24 Quite High
Prion Diseases 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Creutzfeldt Jakob Disease 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, under these conditions the reduction in PrPSc was likely due to inhibition of PrPSc production rather than its increased degradation.
Regulation (due) of Negative_regulation (reduction) of PrPSc
1) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
UTR in the human PRNP gene does not contain the PrP siRNA target sequence, and HEK 293 cells thus serve as an additional negative control for PrP siRNA-specific suppression of murine PrPC.
Regulation (control) of Negative_regulation (suppression) of PrP
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.33 Pain Relevance 0

General Comments

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