INT268171

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 30 97.84 Very High Very High Very High
adenocard 2 69.92 Quite High
depression 6 49.52 Quite Low
nMDA receptor 13 35.08 Quite Low
Glutamate 2 12.84 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.56 Very High Very High Very High
Scrapie 21 97.72 Very High Very High Very High
Disease 73 89.20 High High
Prion Diseases 35 86.64 High High
Psychosis 1 74.56 Quite High
Targeted Disruption 24 64.04 Quite High
Alzheimer's Dementia 17 50.00 Quite Low
Depression 6 49.52 Quite Low
Coronary Artery Disease 2 41.72 Quite Low
Creutzfeldt Jakob Disease 16 34.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, it is possible that impairment of PrP recycling in GFP-Rab22a expressing cells could divert PrP towards a degradation pathway.
Negative_regulation (impairment) of PrP Binding (recycling) of
1) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Quinacrine, chlorpromazine, and some of their tricyclic derivatives were described as efficient inhibitors of PrPSc formation in murine neuroblastoma cells chronically infected with scrapie [32], [33].
Negative_regulation (inhibitors) of PrPSc Binding (formation) of associated with neuroblastoma and scrapie
2) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.64 Pain Relevance 0
oligomers to PrP(C) can be blocked by anti-PrP antibodies, and the inhibitory effect on LTP is suppressed.48 Whether PrP(C) plays a critical role in recognizing A?
Negative_regulation (blocked) of PrP Binding (oligomers) of associated with long-term potentiation
3) Confidence 0.06 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938309 Disease Relevance 0.18 Pain Relevance 0.25

General Comments

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