INT268188

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp, Erc1) cytoplasm (Prnp, Erc1) transport (Erc1)
endoplasmic reticulum (Prnp) nucleolus (Prnp) plasma membrane (Prnp)
Prnp (Mus musculus)
Erc1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 26 99.32 Very High Very High Very High
Disease 12 62.80 Quite High
Amyloid Plaque 2 61.16 Quite High
Infection 16 42.48 Quite Low
Creutzfeldt Jakob Disease 16 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the results described in the previous paragraph indicate that the recycling of PrP through the ERC is required for scrapie production.
PrP Binding (recycling) of ERC associated with scrapie
1) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
Furthermore, the observation that cholesterol redistribution from other cellular compartments to LEs, induced by U18666A treatment, impairs PrP trafficking from EEs to the ERC (Figure 2C) suggests that cholesterol is not only important for GPI-AP retention within the ERC, but might also be required for its sorting from EEs to the ERC.
PrP Binding (trafficking) of ERC
2) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.18 Pain Relevance 0

General Comments

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