INT268191

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rab4a, Prnp) endosome (Rab4a) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) GTPase activity (Rab4a) cytoplasm (Prnp)
Rab4a (Mus musculus)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 13 87.52 High High
Creutzfeldt Jakob Disease 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Amyloid Plaque 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this hypothesis expression of a dominant-negative Rab4 mutant (GFP-Rab4N121I), which impairs recycling from EEs [40], did not affect PrPSc levels in either ScGT1 or ScN2a cells (Figure S6).
Rab4 mutant Regulation (affect) of Gene_expression (levels) of PrPSc
1) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.22 Pain Relevance 0

General Comments

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