INT268195

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rab22a, Prnp) endosome (Rab22a) transport (Rab22a)
Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) GTPase activity (Rab22a)
Rab22a (Mus musculus)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 13 86.48 High High
Creutzfeldt Jakob Disease 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Amyloid Plaque 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We reasoned that if the reduction of PrPSc by Rab22a was due to increased lysosomal degradation, a block of the lysosomal function with NH4Cl should revert its effect and result in unchanged or increased PrPSc levels.
Rab22a Negative_regulation (reduction) of PrPSc
1) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.09 Pain Relevance 0

General Comments

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