INT268198

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp, Erc1) cytoplasm (Prnp, Erc1) transport (Erc1)
endoplasmic reticulum (Prnp) nucleolus (Prnp) plasma membrane (Prnp)
Prnp (Mus musculus)
Erc1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 26 95.08 Very High Very High Very High
Coronary Artery Disease 4 78.16 Quite High
Creutzfeldt Jakob Disease 16 5.00 Very Low Very Low Very Low
Infection 16 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Amyloid Plaque 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To directly test whether PrPC must reach the ERC in order to be converted to PrPSc we analyzed the effect of Rab22a overexpression on PrP sorting and PrPSc production.
PrPC Positive_regulation (reach) of ERC
1) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.18 Pain Relevance 0
Although these data indicate that PrPC must reach the ERC in order to be converted, we had to rule out the possiblity that overexpressed Rab22a was titrating out other cellular sorting factors.
PrPC Positive_regulation (reach) of ERC
2) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0

General Comments

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