INT26824

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Context Info
Confidence 0.54
First Reported 1989
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.42
Pain Relevance 6.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Crh, Penk) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
globus pallidus 2
pallidum 2
Crh (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 56 100.00 Very High Very High Very High
Dynorphin 38 100.00 Very High Very High Very High
noradrenaline 10 98.80 Very High Very High Very High
antagonist 20 96.52 Very High Very High Very High
Opioid 145 94.48 High High
tetrodotoxin 3 91.40 High High
narcan 11 87.36 High High
cytokine 7 86.84 High High
opioid receptor 97 86.56 High High
Inflammatory response 1 81.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 81.44 Quite High
Stress 18 74.64 Quite High
Pain 37 50.00 Quite Low
Nociception 9 46.68 Quite Low
Adhesions 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Met-ENK release was significantly stimulated by corticotropin-releasing hormone (CRH; 10(-12)-10(-8) M), an effect which was abolished in the presence of the CRH-receptor antagonist, alpha-helical CRF9-41 (10(-6) M).
corticotropin-releasing hormone Positive_regulation (stimulated) of Localization (release) of Met-ENK associated with antagonist
1) Confidence 0.54 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.47
Met-ENK release was significantly stimulated by corticotropin-releasing hormone (CRH; 10(-12)-10(-8) M), an effect which was abolished in the presence of the CRH-receptor antagonist, alpha-helical CRF9-41 (10(-6) M).
CRH Positive_regulation (stimulated) of Localization (release) of Met-ENK associated with antagonist
2) Confidence 0.54 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.47
Corticotropin-releasing factor stimulates the release of methionine-enkephalin and dynorphin from the neostriatum and globus pallidus of the rat: in vitro and in vivo studies.
Corticotropin-releasing factor Positive_regulation (stimulates) of Localization (release) of methionine-enkephalin in globus pallidus associated with dynorphin and enkephalin
3) Confidence 0.48 Published 1989 Journal Brain Res. Section Title Doc Link 2569903 Disease Relevance 0 Pain Relevance 0.98
Both the in vitro and in vivo studies thus demonstrate that CRF can exert potent effects on Met-enkephalin and dynorphin release within the neostriatum-pallidum of the rat and that such effects are mediated via receptors specific for CRF, probably located on both the cell bodies and terminals of these opioid-containing neurones.
CRF Positive_regulation (exert) of Localization (release) of Met-enkephalin in pallidum associated with dynorphin, enkephalin and opioid
4) Confidence 0.45 Published 1989 Journal Brain Res. Section Abstract Doc Link 2569903 Disease Relevance 0 Pain Relevance 1.38
It was found that the basal and CRH-induced release of Met-ENK was not changed 1 week after castration.
CRH Positive_regulation (induced) of Localization (release) of Met-ENK
5) Confidence 0.44 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.50
In the in vitro studies, CRF (10(-12), 10(-10) and 10(-8) M) (applied in pulses of 75 min) stimulated both Met-enkephalin and dynorphin release from the neostriatal slices in a dose-related manner; in the presence of the CRF receptor antagonist, alpha-helical CRF9-41 (10(-6) M) the release of both Met-enkephalin and dynorphin in response to CRF (10(-8) M) were completely blocked.
CRF Positive_regulation (stimulated) of Localization (release) of Met-enkephalin associated with dynorphin, antagonist and enkephalin
6) Confidence 0.39 Published 1989 Journal Brain Res. Section Abstract Doc Link 2569903 Disease Relevance 0 Pain Relevance 1.30
CRF induces the release of END, ENK, and DYN (Cabot et al 2001); noradrenaline releases END (Binder et al 2004; Mousa et al 2004); and IL-1?
CRF Positive_regulation (induces) of Localization (release) of ENK associated with noradrenaline and enkephalin
7) Confidence 0.07 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.42 Pain Relevance 1.38

General Comments

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