INT268264

Context Info Confidence 0.44 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 6.10 Pain Relevance 1.09

Anatomy Link Frequency lungs 2 prefrontal 2 body 2 hb (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 276 99.64 Hippocampus 21 98.24 Eae 36 49.84 Neurobehavioral 6 45.56 withdrawal 6 45.52 depression 9 38.96 monoamine 39 35.68 Central nervous system 9 33.12 Inflammation 24 18.64 ischemia 13 10.08

Disease Link Frequency Relevance Heat Targeted Disruption 331 99.84 Idiopathic Pulmonary Fibrosis 276 99.64 Ganglion Cysts 3 99.24 Pulmonary Disease 256 98.40 Body Weight 10 95.40 Disease 71 94.12 Chronic Renal Failure 16 90.08 Hypoxia 13 88.88 Stress 28 87.28 Nicotine Addiction 36 84.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the prefrontal cortex, the expression of Hb-egf mRNA and protein were found to be considerably reduced in KO mice (Fig. 1d).

Negative_regulation (reduced) of Gene_expression (expression) of Hb-egf in prefrontal associated with targeted disruption

1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.90 Pain Relevance 0.13

Despite the decreased expression HB-EGF, the overall development of HB-EGF KO mice appeared to be normal and there were no significant differences in the body weight in the adult KO or control mice.

Negative_regulation (decreased) of Gene_expression (expression) of HB-EGF in body associated with targeted disruption and body weight

2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.20 Pain Relevance 0.05

For a further examination of the expression of Hb-egf mRNA and its protein in HB-EGF KO and control mice, we performed in situ hybridization analysis and immunohistrochemical analysis respectively (Fig. 1d).

Negative_regulation (examination) of Gene_expression (expression) of Hb-egf associated with targeted disruption

3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.78 Pain Relevance 0.13

Before any intervention, HbT concentration was measured as approximately 70 ?

Negative_regulation (measured) of Gene_expression (concentration) of HbT

4) Confidence 0.28 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0.15 Pain Relevance 0

Hb increases occurred in each dose group with mean Hb increases of 0.31, 0.70, and 1.76 g/dL during the first 6 weeks in the 0.15, 0.30, and 0.60 ?

Negative_regulation (occurred) of Gene_expression (increases) of Hb

5) Confidence 0.19 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.17 Pain Relevance 0

The levels of Hb complexes declined only in IPF for reasons that remain unclear.

Negative_regulation (declined) of Gene_expression (levels) of Hb associated with fibrosis

6) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.62 Pain Relevance 0.15

Alkylation prior to separation abolished the presence of Hb?

Negative_regulation (abolished) of Gene_expression (presence) of Hb

7) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.50 Pain Relevance 0.18

Overall, the reduced levels of the Hb?

Negative_regulation (reduced) of Gene_expression (levels) of Hb

8) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.68 Pain Relevance 0.21

Decline of Hb complexes and monomers in the IPF but not in the COPD lungs

Negative_regulation (Decline) of Gene_expression (complexes) of Hb in lungs associated with fibrosis and pulmonary disease

9) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.11 Pain Relevance 0.24

General Comments

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