INT268264

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.10
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 2
prefrontal 2
body 2
hb (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 276 99.64 Very High Very High Very High
Hippocampus 21 98.24 Very High Very High Very High
Eae 36 49.84 Quite Low
Neurobehavioral 6 45.56 Quite Low
withdrawal 6 45.52 Quite Low
depression 9 38.96 Quite Low
monoamine 39 35.68 Quite Low
Central nervous system 9 33.12 Quite Low
Inflammation 24 18.64 Low Low
ischemia 13 10.08 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 331 99.84 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 276 99.64 Very High Very High Very High
Ganglion Cysts 3 99.24 Very High Very High Very High
Pulmonary Disease 256 98.40 Very High Very High Very High
Body Weight 10 95.40 Very High Very High Very High
Disease 71 94.12 High High
Chronic Renal Failure 16 90.08 High High
Hypoxia 13 88.88 High High
Stress 28 87.28 High High
Nicotine Addiction 36 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the prefrontal cortex, the expression of Hb-egf mRNA and protein were found to be considerably reduced in KO mice (Fig. 1d).
Negative_regulation (reduced) of Gene_expression (expression) of Hb-egf in prefrontal associated with targeted disruption
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.90 Pain Relevance 0.13
Despite the decreased expression HB-EGF, the overall development of HB-EGF KO mice appeared to be normal and there were no significant differences in the body weight in the adult KO or control mice.
Negative_regulation (decreased) of Gene_expression (expression) of HB-EGF in body associated with targeted disruption and body weight
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.20 Pain Relevance 0.05
For a further examination of the expression of Hb-egf mRNA and its protein in HB-EGF KO and control mice, we performed in situ hybridization analysis and immunohistrochemical analysis respectively (Fig. 1d).
Negative_regulation (examination) of Gene_expression (expression) of Hb-egf associated with targeted disruption
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.78 Pain Relevance 0.13
Before any intervention, HbT concentration was measured as approximately 70 ?
Negative_regulation (measured) of Gene_expression (concentration) of HbT
4) Confidence 0.28 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0.15 Pain Relevance 0
Hb increases occurred in each dose group with mean Hb increases of 0.31, 0.70, and 1.76 g/dL during the first 6 weeks in the 0.15, 0.30, and 0.60 ?
Negative_regulation (occurred) of Gene_expression (increases) of Hb
5) Confidence 0.19 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.17 Pain Relevance 0
The levels of Hb complexes declined only in IPF for reasons that remain unclear.
Negative_regulation (declined) of Gene_expression (levels) of Hb associated with fibrosis
6) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.62 Pain Relevance 0.15
Alkylation prior to separation abolished the presence of Hb?
Negative_regulation (abolished) of Gene_expression (presence) of Hb
7) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.50 Pain Relevance 0.18
Overall, the reduced levels of the Hb?
Negative_regulation (reduced) of Gene_expression (levels) of Hb
8) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.68 Pain Relevance 0.21
Decline of Hb complexes and monomers in the IPF but not in the COPD lungs
Negative_regulation (Decline) of Gene_expression (complexes) of Hb in lungs associated with fibrosis and pulmonary disease
9) Confidence 0.17 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.11 Pain Relevance 0.24

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