INT2683

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 7.98
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
neuronal 2
plasma 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 40 99.76 Very High Very High Very High
glial activation 1 99.72 Very High Very High Very High
Clonidine 7 99.38 Very High Very High Very High
Pain 5 93.20 High High
cINOD 3 83.68 Quite High
Central nervous system 1 75.88 Quite High
Inflammation 9 70.56 Quite High
anesthesia 3 50.00 Quite Low
epidural 1 50.00 Quite Low
spastic colon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paratuberculosis 400 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Diabetes Mellitus 435 99.64 Very High Very High Very High
Disease 68 99.46 Very High Very High Very High
Stress 5 99.32 Very High Very High Very High
Death 2 98.32 Very High Very High Very High
Enteritis 10 97.48 Very High Very High Very High
Hypertension 1 96.64 Very High Very High Very High
Aging 3 93.00 High High
Infection 35 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific enzymes, including cytosolic phospholipase A2, MAP kinases, lipoxygenases and cyclooxygenases, associate with lipid bodies.
MAP Binding (associate) of
1) Confidence 0.36 Published 1997 Journal Mem. Inst. Oswaldo Cruz Section Abstract Doc Link 9698925 Disease Relevance 0.14 Pain Relevance 0.15
Long-term clonidine therapy resulted in decreased MAP and RVR associated with the suppression of supine but not upright PRA.
MAP Binding (associated) of associated with clonidine
2) Confidence 0.35 Published 1979 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 498699 Disease Relevance 0.10 Pain Relevance 0.61
Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), oxidative stress and neuronal cell death.
MAP Binding (crosslinking) of in neuronal associated with stress, alzheimer's dementia, disease and death
3) Confidence 0.35 Published 1997 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 9063589 Disease Relevance 1.01 Pain Relevance 0.08
Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), glial activation, oxidative stress and neuronal cell death.
MAP Binding (crosslinking) of in neuronal associated with stress, alzheimer's dementia, disease, death and glial activation
4) Confidence 0.35 Published 2002 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 12456073 Disease Relevance 0.92 Pain Relevance 0.13
The post-induction value of this parameter was closely associated with MAP but not with the patient's age.


MAP Binding (associated) of
5) Confidence 0.35 Published 2007 Journal Acta Anaesthesiol Scand Section Body Doc Link 17635395 Disease Relevance 0 Pain Relevance 0
One of important observations that we recorded during this study was the absence of any significant association between MAP and the T2DM.
MAP Binding (association) of associated with diabetes mellitus and paratuberculosis
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.41 Pain Relevance 0.03
In this case, secondary anti human IgG conjugated with alkaline phosphatase shall bind to the anti MAP previously bound.
MAP Binding (bound) of associated with paratuberculosis
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 0.99 Pain Relevance 0
In this case, secondary anti human IgG conjugated with alkaline phosphatase shall bind to the anti MAP previously bound.
MAP Binding (bound) of associated with paratuberculosis
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 0.99 Pain Relevance 0
While the proposed association of MAP with Crohn's disease poses a grave proposal [1], [2], [3], more alarming is its putative link to the type-1 diabetes mellitus (T1DM) [4], [5], [6].
MAP Binding (association) of associated with crohn's disease, diabetes mellitus, paratuberculosis and disease
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.34 Pain Relevance 0.19
Given the fact that in the plasma of patients (where MAP is present), antibodies against MAP shall be present and these antibodies are likely to bind to the phage-trapped MAP cells.
MAP Spec (likely) Binding (bind) of in plasma associated with paratuberculosis
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.09 Pain Relevance 0

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