INT268325

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ptgs2) intracellular (Lep) enzyme binding (Ptgs2)
protein complex (Ptgs2) cytoplasm (Ptgs2) lipid metabolic process (Lep)
Anatomy Link Frequency
endothelium 1
Lep (Mus musculus)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 77.36 Quite High
Inflammation 2 73.68 Quite High
ischemia 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 48 82.96 Quite High
INFLAMMATION 3 73.68 Quite High
Insulin Resistance 7 15.44 Low Low
Hyperphagia 2 14.16 Low Low
Metabolic Syndrome 4 13.44 Low Low
Syndrome 3 11.84 Low Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Weight Gain 5 5.00 Very Low Very Low Very Low
Hyperglycemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated concentration of glucose and leptin increase respectively cyclooxygenase-2 (Cox2) and cyclooxygenase-1 (Cox1) gene expression promoting synthesis of prostacyclin and prostaglandins with protective activity on endothelium [35].
leptin Positive_regulation (increase) of cyclooxygenase-2 in endothelium
1) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.39 Pain Relevance 0.08

General Comments

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