INT26833

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.50
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
lower urinary tract 1
duodenum 1
oocytes 1
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 29 100.00 Very High Very High Very High
opiate 5 99.88 Very High Very High Very High
Nicotine 8 99.84 Very High Very High Very High
adenocard 7 99.24 Very High Very High Very High
narcan 1 99.24 Very High Very High Very High
Analgesic 1 99.24 Very High Very High Very High
Antinociceptive 2 97.40 Very High Very High Very High
Potency 73 97.36 Very High Very High Very High
Inflammation 5 97.36 Very High Very High Very High
agonist 89 94.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 97.36 Very High Very High Very High
Arthritis 2 96.28 Very High Very High Very High
Disease 2 92.64 High High
Stress Incontinence 1 91.52 High High
Overactive Bladder 1 87.84 High High
Pain 3 86.92 High High
Lower Urinary Tract Symptoms 4 85.36 High High
Coagulation Disorder 4 85.32 High High
Stress 1 79.68 Quite High
Benign Prostatic Hypertrophy 4 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All purinergic compounds produced an increase in excitability, however, only the effects of alpha,beta-meATP and of Ap5A were strongly reduced by 2'- (or 3') -O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), a selective blocker for P2X1, P2X3, and heteromeric P2X2/3 receptors.
Negative_regulation (blocker) of P2X
1) Confidence 0.41 Published 2001 Journal Neuroreport Section Abstract Doc Link 11277562 Disease Relevance 0 Pain Relevance 0.25
We used the irreversible inhibitor of P2z/P2X7 receptor, designated oxidized ATP (oATP), to test its possible antinociceptive activity in arthritic rats.
Negative_regulation (inhibitor) of P2X associated with antinociceptive and arthritis
2) Confidence 0.41 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12098642 Disease Relevance 0.41 Pain Relevance 0.31
However, it is clear that common ATP binding sequences, e.g. the Walker motif (10), are not present in P2X receptors.
Neg (not) Negative_regulation (present) of P2X
3) Confidence 0.41 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0.43 Pain Relevance 0.17
P2X1 receptors that were treated in 300 ?
Negative_regulation (treated) of P2X
4) Confidence 0.41 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.04
All purinergic compounds produced an increase in excitability, however, only the effects of alpha,beta-meATP and of Ap5A were strongly reduced by 2'- (or 3') -O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), a selective blocker for P2X1, P2X3, and heteromeric P2X2/3 receptors.
Negative_regulation (blocker) of P2X1
5) Confidence 0.38 Published 2001 Journal Neuroreport Section Abstract Doc Link 11277562 Disease Relevance 0 Pain Relevance 0.25
Lanthanum and gadolinium blocked P2X1 and P2X2 currents in oocytes; this inhibition appeared competitive and was reversed by increasing the ATP concentration (Nakazawa et al., 1997).
Negative_regulation (blocked) of P2X1 in oocytes
6) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.06
Nicotine-induced relaxation of adult duodenum was significantly inhibited by preincubation with alpha-chymotrypsin, a proteolytic enzyme, and a combination of nucleotide pyrophosphatase and 8-phenyltheophylline, a P1 purinoceptor antagonist.
Negative_regulation (antagonist) of P1 purinoceptor in duodenum associated with antagonist and nicotine
7) Confidence 0.16 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8137872 Disease Relevance 0 Pain Relevance 0.63
Purinoceptors are currently the focus of interest as treatment targets in the lower urinary tract and inhibitors of P2X3 (and P2X1) subtypes may offer new opportunities.
Negative_regulation (inhibitors) of P2X1 in lower urinary tract
8) Confidence 0.09 Published 2002 Journal World J Urol Section Abstract Doc Link 12022712 Disease Relevance 0.65 Pain Relevance 0.37
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
Negative_regulation (autoreceptors) of P1-purinergic associated with adenocard and opiate
9) Confidence 0.03 Published 1989 Journal J. Neurochem. Section Title Doc Link 2570125 Disease Relevance 0 Pain Relevance 0.81

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